26. Epigenetics of Heart Failure Flashcards Preview

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Flashcards in 26. Epigenetics of Heart Failure Deck (20):
1

DNA acetylation (and other modifications) occurs on the ____ residues.

lysine

2

____ extend beyond the nucleosome and are sites of post-translational modification.

Histone tails

3

What does HDC stand for?

histone deacetylase

3

____ Stimulates Cardiac Hypertrophy in Mice.

HDAC9 Gene Knockout

4

What is the histone code?

a code read by proteins; consists of all the histone modifications; determines whether RNA pol II engages with DNA

4

HDAC9 Overexpression Blocks _______.

Cardiomyocyte Hypertrophy

5

_____ are good drug targets.

The enzymes that regulate epigenetic processes

6

What is the octameric,, basic unit of chromatin called?

a nucleosome

8

The hallmarks of cardiac hypertrophy are ____, ____, and ____.

new protein synthesis sarcomere assembly gene expression

9

Name 3 ways gene expression can be altered w/o changing the DNA sequence.

1. histone modifications 2. chromatin remodling 3. DNA methylation

9

Epigenetic marks are created and controlled by ____.

enzymes

9

HDAC9 Gene Knockout Stimulates _____ in Mice.

Cardiac Hypertrophy

11

What does a HAT do?

write the histone code by adding acetyl groups to lysines- turns genes on

12

The enzymes that regulate epigenetic processes are good ____.

drug targets

15

What is chromatin?

DNA + histones (proteins)

16

Abnormal epigenetics can contribute to the development of ______, such as ____.

cardiomyopathy; cardiac hypertrophy

17

_____ Overexpression Blocks Cardiomyocyte Hypertrophy.

HDAC9

18

What does HAT stand for?

histone acetyltranferase

19

What does an HDC do?

erases the histone code by deleting the acetyl groups from lysines- turns gene off

20

DNA methylation occurs on ____ residues of _____ dinucleotides.

cystosine; CpG