DNA acetylation (and other modifications) occurs on the ____ residues.
____ extend beyond the nucleosome and are sites of post-translational modification.
What does HDC stand for?
____ Stimulates Cardiac Hypertrophy in Mice.
HDAC9 Gene Knockout
What is the histone code?
a code read by proteins; consists of all the histone modifications; determines whether RNA pol II engages with DNA
HDAC9 Overexpression Blocks _______.
_____ are good drug targets.
The enzymes that regulate epigenetic processes
What is the octameric,, basic unit of chromatin called?
The hallmarks of cardiac hypertrophy are ____, ____, and ____.
new protein synthesis sarcomere assembly gene expression
Name 3 ways gene expression can be altered w/o changing the DNA sequence.
1. histone modifications 2. chromatin remodling 3. DNA methylation
Epigenetic marks are created and controlled by ____.
HDAC9 Gene Knockout Stimulates _____ in Mice.
What does a HAT do?
write the histone code by adding acetyl groups to lysines- turns genes on
The enzymes that regulate epigenetic processes are good ____.
What is chromatin?
DNA + histones (proteins)
Abnormal epigenetics can contribute to the development of ______, such as ____.
cardiomyopathy; cardiac hypertrophy
_____ Overexpression Blocks Cardiomyocyte Hypertrophy.
What does HAT stand for?
What does an HDC do?
erases the histone code by deleting the acetyl groups from lysines- turns gene off
DNA methylation occurs on ____ residues of _____ dinucleotides.