27. Bile Flashcards Preview

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Flashcards in 27. Bile Deck (9)
1

Composed of

bile salts (bile acids conjugated to glycine or taurine, making them water soluble),
phospholipids, cholesterol, bilirubin, water, and ions. catalyzes

2

Functions:

ƒƒDigestion and absorption of lipids and fat-soluble vitamins
ƒƒ Cholesterol excretion (body’s only means of eliminating cholesterol)
ƒƒ Antimicrobial activity (via membrane disruption)

3

rate‑limiting step of bile acid synthesis -catalyst

Cholesterol 7α-hydroxylase

4

• What are the six components of bile?

Bile salts, phospholipids, cholesterol, bilirubin, water, and ions

5

• What is the only means of cholesterol excretion from the body?

Via bile

6

• Bile acid conjugation makes bile _____ (more/less) soluble by biding to which two amino acids?

More, glycine and taurine

7

• In a patient who is unable to produce bile, what physiologic functions would be impaired?

Excretion of cholesterol, digestion and uptake of lipids and fat-soluble vitamins, & antimicrobial activity

8

• A patient has defective cholesterol 7&945;-hydroxylase activity. Does this affect his ability to absorb vitamins in any way?

Yes, as this impairs the rate-limiting step of bile synthesis (one of bile's functions is to assist with vitamin digestion and absorption)

9

• In an experiment, bacteria within a Petri dish exposed to gallbladder secretions are noted to perish quickly. What is going on?

Bile has antimicrobial activity via bacterial membrane disruption

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