27. Bile Flashcards Preview

Gastrointestinal > 27. Bile > Flashcards

Flashcards in 27. Bile Deck (9)

Composed of

bile salts (bile acids conjugated to glycine or taurine, making them water soluble),
phospholipids, cholesterol, bilirubin, water, and ions. catalyzes



ƒƒDigestion and absorption of lipids and fat-soluble vitamins
ƒƒ Cholesterol excretion (body’s only means of eliminating cholesterol)
ƒƒ Antimicrobial activity (via membrane disruption)


rate‑limiting step of bile acid synthesis -catalyst

Cholesterol 7α-hydroxylase


• What are the six components of bile?

Bile salts, phospholipids, cholesterol, bilirubin, water, and ions


• What is the only means of cholesterol excretion from the body?

Via bile


• Bile acid conjugation makes bile _____ (more/less) soluble by biding to which two amino acids?

More, glycine and taurine


• In a patient who is unable to produce bile, what physiologic functions would be impaired?

Excretion of cholesterol, digestion and uptake of lipids and fat-soluble vitamins, & antimicrobial activity


• A patient has defective cholesterol 7&945;-hydroxylase activity. Does this affect his ability to absorb vitamins in any way?

Yes, as this impairs the rate-limiting step of bile synthesis (one of bile's functions is to assist with vitamin digestion and absorption)


• In an experiment, bacteria within a Petri dish exposed to gallbladder secretions are noted to perish quickly. What is going on?

Bile has antimicrobial activity via bacterial membrane disruption

Decks in Gastrointestinal Class (88):