28. Vaccination Flashcards Preview

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Flashcards in 28. Vaccination Deck (12):
1

Vaccination induces

an active immune response (humoral/or cellular) to specific antigens

2

Viral vaccines- categories and viruses

A. Live attenuated ( smallpox, 2 yellow fever 3rotavirus 4vZV 5. Sabin polio 6. Influenza (intranasal) 7. Measles 8. Mumps 9. Rubela
B. Killed (1. Rabies 2. Influenza (injected) 3. Salk polio 4. HAV)
C. Subunit (1. HBV (antigen = HBsAg), 2. HPV (types 6.11.16.18)

3

life attenuated vaccine - description

microorganism loses its pathogenicity but retains capacity for transient growth within inoculatted host --> induces cellular and hunoral responses

4

Inactivated or killed vaccine-description

Pathogen is inactivated by heat or chemicals -- maintaining epitope structure on surface antigens is important for immune response ---> mainly induce humoral response

5

Life attenuated vaccine vs inactivated or killed vaccine according to immune response

Life attenuated --> cellular and humoral responses
Inactivated or killed --> humoral response

6

Life attenuated vaccine - pros and cons

pros: induce strong, often lifelong immunity
con : may revert to virulent form

7

Life attenuated vaccine is often contradicated in

pregnancy and immunodeficiency

8

Life attenuated vaccine - HIV

MMR and VZV if cd mor than 2 hundred

9

Inactivated or killed vaccine - pros and con

Pro: safer than live vaccine
Con: weaker immune response (booster shot usually required)

10

live attenuated vaccine but not virus

BCG
salmonella typhi

11

influenza vaccine

live--> intranasal
killed--> injected

12

A pregnant woman asks for a flu vaccine. Is the immune response of the vaccine you administer humoral or cellular?


You use the injected inactivated/killed vaccine, as the live attenuated (intranasal) vaccine is contraindicated in pregnancy