29. Hypoparathyroidism Flashcards Preview

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Flashcards in 29. Hypoparathyroidism Deck (17):
1

hypoparathyroidism due to

accidental surgical excision of parathyroid glands, autoimmune destruction, or DiGeorge
syndrome. Findings: tetany, hypocalcemia, hyperphosphatemia

2

finding s and symptoms

tetany, hypocalcemia, hyperphosphatemia.

3

2 signs in clinical examinatiον

1. Chostek sign
2. Trousseau sign

4

Chostek sign - defintion and when

tapping of facial nerve (tap the Cheek) --> contraction of facial muscles

5

Trousseau sign - defintion and when

sign—occlusion of brachial artery with BP cuff (cuff the Triceps)-->carpal spasm

6

labs

1. decreased PTH
2. decreased calcium

7

pseudohypoparathyroidism is also called

ALbrigh hereditary osteodystrophy

8

Albrigh hereditary osteodystrophy is also called

pseudohypoparathyroidism

9

Albrigh hereditary osteodystrophy (pseudohypoparathyroidism) - mechanism

Due to defective Gs protein α-subunit causing end-organ
resistance to PTH.—unresponsiveness of
kidney to PTH --> hypocalcemia despite increased PTH levels.

10

Albrigh hereditary osteodystrophy (pseudohypoparathyroidism) - mode of inheritence

AD
must be inherited from mother due to imprinting

11

unresposiveness of kidney to PTH

Albrigh hereditary osteodystrophy (pseudohypoparathyroidism)

12

Albrigh hereditary osteodystrophy (pseudohypoparathyroidism) - labs

1. increased PTH
2. decreased calcium

13

Albrigh hereditary osteodystrophy (pseudohypoparathyroidism) - clinical findings

1. short staure
2. shortened 4th / 5th digits

14

Pseudopseudohypoparathyroidism—physical exam

physical exam features of Albright hereditary
osteodystrophy but without end-organ PTH resistance.

15

Pseudopseudohypoparathyroidism mechanism

Occurs when defective Gs protein
α-subunit is inherited from father.

16

List three causes of hypoparathyroidism.

Accidental surgical excision (thyroid surgery), autoimmune destruction, and DiGeorge syndrome

17

A man with DiGeorge syndrome exhibits Chvostek and Trousseau signs. What is the difference between these signs?

Chvostek: facial muscle (cheek) contraction w/ facial nerve tap; Trousseau: carpal spasm w/ brachial artery occlusion w/ BP cuff (triceps)