Flashcards in 29. Pneumoconioses Deck (59):
pneuconosioses - types
3. Coal workers pnemoconiosis
pneumoconioses ( except beryliosis ) - increased risk for
1. cor pulmonale
2. Caplan syndrome
rheumatoid arthritis and pneumoconiases ( coal , asbestosis, silicosis ) with intrapulmonary nodules
Asbestosis is associated with ( xposure)
pathognomonic lesions of asbesrosis ( gross)
Ivory white, calcified supreadiaphragmatic and pleural plaques
areas of asbestos plaques
2. pleural plaques
carcinomas associated with asvestosis
1. bronchogenic ca> mesothelioma
asbestosis affect (area)
asbestosis affect ( area)
berrylliosis associated with (exposure)
2. manufacturing industries
lung asbestosis - histology
ferruginous ( asbestos) bodies : goldern - brown fusiform rods resembling dumbbels, found in alveolar septum ( visuliazed using PAS stain), often obtain by branchoalveolar lavage)
ferruginous bodies are found in
berryliosis affects ( area)
noncaseasting granoulomas in lung, hilar lymph nodes and systemic organs
noncaseating granoulomas in lung, hilar lymph nodes and systemic organs
occasionally responsive to steriods
Coal workers pneuconiosis is also known s
black lung disease
Coal workers pneuconiosis affects (area)
Coal workers pneuconiosis - pathophysiology
prolonged coal dust exposure --> macrophages laden with carbon --> inflammation and fibrosis
Anthracosis is caused by
mild exposure to carbon ( collection of macrophages laden with carbon )
Anthracosis- symptoms / found in
asympotmatic condition found in many urban dwellers exposed to sooty air
Anthracosis - occupation
found in many urban dwellers exposed to sooty air
Silicosis is associated with .... ( occupation )
1. foundries ( factory that produces metal castings)
Silicosis - pathophysiology
Macrophages respond to silica and release fibrogenic factors, leading to fibrosis. It is thought that silica may disrypt phagolysosomes and impair macrophages
Silicosis - increased risk for
2. bronchogenic carcinoma
Silicosis affects ( area)
Silicosis - CXR
Eggshell calcification of hilar lymph nodes
pneumoconiases that affect upper lobes
1. coal worker;s pneumoconiosis
pneumoconiases that affect lower lobes
pneumoconiases - increased risk for TB
fibrotic nodules found in upper lobes
fibrosis of lung and pleura ( plaques)
pneumoconiases - roofing
pneumoconiases -eggshel apperance
pneumoconiases - black lung disease
coal worker's pneumoconiosis
pneumoconiases -ferruginous bodies
pneumoconiases - fibrosis
2. coal worker's pneumoconiosis
pneumoconiases - respond to steroids
Berryliosis ( occaionally responsive)
rheuamtoid athritis and pneumoconiases with intrapulmonary nodules =?
pneumoconiases - disrupts phagolysosomes
pneumoconiases - types and affexted area of lung
1. coal worker;s pneumoconiosis
2. Silicosis ---> upper lobes ---> upper lobes
3. Berylliosis ---> upper lobes
4. Asbestosis --> lower lobes
Ferruginous bodies are visualized using
Prusian blue stain
asbestois also increases the risk of
• Silicosis, coal workers' pneumoconiosis, and asbestosis are associated with increased risk of what two other diseases?
Cor pulmonale and Caplan syndrome (the combination of pneumoconiosis and rheumatoid arthritis)
• What occupations are associated with exposure to asbestos?
Shipbuilding, roofing, and plumbing
• Asbestosis mainly affects the ____(lower/upper) lung lobe(s), whereas silica and coal workers' lung affects the ____(lower/upper) lobe(s).
• A patient who works in an aerospace company is at risk for which type of pneumoconiosis?
Berylliosis, as working in the aerospace or manufacturing industries increases one's risk for beryllium exposure
• A patient presents with shortness of breath and cough. He works for a local aerospace manufacturing plant. Treatment?
Steroids, as granulomas arise in berylliosis that may respond to this treatment
• Which lobes of the lungs are affected in a patient with berylliosis?
• Explain the pathogenesis of coal workers' pneumoconiosis (also known as black lung disease).
Prolonged exposure to coal dust results in carbon within macrophages, which leads to inflammation and fibrosis in the lungs
• Which lobes of the lungs are most affected by coal miners' disease?
• A patient is diagnosed with anthracosis. How does this differ from coal workers' pneumoconiosis.
Anthracosis is the result of exposure to sooty air in the city versus coal dust in coal workers (it is asymptomatic)
• Patients with silicosis typically work in which three fields?
Foundries, sandblasting, mining
• A foundry worker has dyspnea and cough. Chest X-ray shows calcification of his hilar lymph nodes. What cell type is responsible?
Macrophages respond to silica exposure by releasing fibrogenic factors, leading to fibrosis of the lungs (the patient has silicosis)
• How does silicosis increase the risk of susceptibility to tuberculosis?
Silica impairs macrophage phagolysosomes, affecting their ability to effectively kill microbes
• A sandblaster has egg-shell calcification on chest X-ray. What disorders is this patient at increased risk of developing?
This patient has silicosis, increasing risk for TB and bronchogenic carcinoma
• A foundry worker has dyspnea and cough. Chest X-ray shows hilar lymph node calcifications. He is at increased risk of what cancer type?
• Which lobes of the lung are most affected by silicosis?