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Flashcards in 3. Sinusoids of spleen Deck (10):
1

spleen parenchyma is divided to

1.white pulp- centrally
2.red pulp-rbcs - peripherally
3. Marginal zone between red pulp and white pulps

2

spleen sinusoids

long vascular channels in red pulp with fenestrated " barrel hoop: basement membran

3

spleen cells and their location

t cell:periarteriolar ly,phatic sheath - white pulp
Bcell: follicles- white pulp
Macrophages and specializidcells: marginal zone
macrophagrs: cords of bilroth -red pulp

4

role of marginal zone

it contains macrophages and specialized B cells--> APCs capture blood - brone antigens dor recognition by lymphocytes

5

Which cells remove encapsulated bacteria in the spleen?

Macrophages near the sinusoids of the spleen

6

A patient with a splenectomy has recurrent infections with encapsulated organisms. Why?

Splenic dysfunction ---> low IgM synthesis--> decreased complement activation---> decreased C3b opsonization --> increased susceptibility to encapsulated organisms

example --> postsplenectomy,2 sickle cell anemia

7

POst-splenectomy lab finds 4

1. Howell Jolly bodies - nuclear remnants
2.Target cell
Thrombocytosis (losss of sequenstration and removal)
4. Lymphocytosis ( loss of sequenstration

8

A patient with sickle cell disease has recurrent infections by specific bacteria. Which bacteria is this patient most susceptible to?

Encapsulated organisms
PnSSKIES
Pseudomonas
N.meningitidis,
S.pneumoniae,
Streptococcus group b
K.pneumoniae
H.influenzae
,E.coli,
Salmonellaspp.,

9

spleen follicle antomy

germinal center in middle --> mantle zone --> marginal zone

10

types of circulation

1. open circulation (sinusoids
2.closed circulation