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Flashcards in 3. Tissue Repair Deck (23):
0

Refers to growth of cells and tissues to replace lost structures, such as the growth of an amputated lb in amphibians:

Regeneration

1

Tissue response to wound, to inflammatory processes in internal organs, or to cell necrosis in organs incapable regeneration:

Healing/repair

2

In parenchymal organs, the replacement of inflammatory infiltrates by granulation tissue and ultimately fibrosis:

Organization

3

Extensive deposition of collagen:

Fibrosis

4

Continuous dividing cells which proliferate throughout life, replacing those that are deatroyed:

Labile cells (surface epithelia of skin, oral cavity, vagina, and cervix)

5

Quiescent tissues which normally have a low level of replication but can undergo rapid division in response to stimuli:

Stable cells (parenchymal cells of liver , kidneys and pancreas)

6

Nondividing tissues which contain cells that have left the cell cycle and cannot undergo mitotic division in postnatal life:

Permanent cells (neurons, skeletal and cardiac muscle)

7

Growth factors and cytokines in repair and regeneration: monocyte chemotaxis:

1. Chemokines
2. TNF
3. PDGF
4. FGF
5. TGF-beta

8

Growth factors and cytokines in repair and regeneration: fibroblast migration/replication:

1. PDGF
2. EGF
3. FGF
4. TGF- beta
5. TNF
6. IL-1

9

Growth factors and cytokines in repair and regeneration: keratinocyte replication:

1. HB-EGF
2. FGF-7
3. HGF(scatter factor)

10

Growth factors and cytokines in repair and regeneration: angiogenesis: chronic inflammation

1. VEGF
2. Angiopoietins
3. FGF

11

Growth factors and cytokines in repair and regeneration: collagen synthesis: fibrosis

1. TGF- beta
2. PDGF

12

Growth factors and cytokines in repair and regeneration: collagen secretion:

1. PDGF
2. FGF
3. TNF

13

What are the functions of Extracellular matrix:

1. Mechanical support
2. Control of cell growth
3. Maintenance of cell differentiation
4. Scaffolding for tissue renewal
5. Eatablishment of tissue microenvironments
6. Storage and presentation of regulatory molecules

14

Type of signaling where cells respond to signaling molecules that they themselves secrete, thus establishing an autocrine loop:

Autocrine signaling

15

Type of signaling where one cell type produces the ligand, which then acts on adjacent target cells that express the appropriate receptors:

Paracrine signaling

16

Type of signaling where hormone are synthesized by cells of endocrine organs and act on target cells distant from their site of synthesis, being usually carried by the blood:

Endocrine signaling

17

Most abundant and most common protein in the human body providing extracellular framework for all multicellular organisms; organizes and strengthens extracellular matrix:

Collagen (triple helix of 3 polypeptide alpha chains, having a gly-x-y repeated sequence)

Note: only protein that undergoes final modification in the RER (not in the golgi apparatus)

18

What are the 5 fibrillar collagen?

Type I, II, III, V, and XI

19

What are those non-fibrillar collagen?

Type IV

20

Vitamin that is required for hydroxylation of procollagen, a requirement that explains the inadequate wound healing in scurvy:

Vitamin C

21

Type of collagen with tissue distribution and genetic defects:

I - hard and soft tissues
(Osteogenesis imperfecta and ehlers-danlos syndrome)

II - cartilage, IV disk, vitreous
(Achondrogenesis type II)

III - hollow organs and soft tissues
(Ehlers- danlos syndrome)

V - soft tissues and blood vessela
(Ehlers- danlos syndrome)

IX - cartilage, vitreous
(Stickler syndrome)

IV - basement membrane
(Alport syndrome)

VI - microfibrils
(Bethlem myopathy)

VII - dermoepidermal junction
(Epidermolysis bullosa)

IX - cartilage, intervertebral disk
(Multiple epiphyseal dysplasia)

XVII - epidermal cells
(Epidermolysis bullosa)

XV and XVIII - endothelial cells
(Knobloch syndrome (type XIII collagen)

22

Largest protein in the body:

Titin