Flashcards in 30. Neonatal respiratory distress syndrome Deck (21):
surfactant deficiency --> increased alveolar surface tension---> alveolar collapse
lab test predictive for neonatal respiratory distress syndrome
1. lecithin/ sphingomyelin ratio in amniotic fluid -->if more than 2 ---> healthy
-if less than 1.5 ---> predictive of NRDAS
2. foam stability test
3. surfactn / albumin ration
neonatala repsiratory distress syndrome - CXR
ground glass apperance of lung fields
persistently low O2 tension - risk of
2. metabolic acidosis
3. necrotizing enterocolitis
therapeutic supplemental of O2 can result in
1. retinopathy of prematurity
2. intraventricular haemorrhage ( brain)
3. Bronchopulmonary dyplasia
Intraventricular hemorrhage of the newborn is ...
bleeding into the fluid - filled areas ( ventrivles ) inside the brain
2. maternal diabetes
3. C- section deliver
maternal diabetes as a risk factor of nrds
increased fetal insulin ( insulin decreases surfactant production )
c- section delivery as risk factor of nrds
lack of stress induced steroids ( steroids induce synthesis of surfactant )
nrds - tx
1. maternal steroids before birth
2. artificial surfactan for infant
clinical deature after birth
1. hypoxemia with cyanosis
2. increased respiratory efforts ( tachypnea, use of accessory muscles, grunting
• A newborn dies of neonatal respiratory distress syndrome. Lung tissue examined in the lab will reveal a deficiency of what chemical?
• How does the lack of surfactant in neonatal respiratory distress syndrome impair gas exchange in the lungs?
Surfactant deficiency leads to an increase in surface tension, resulting in collapse of the alveoli
• What is used as a measure of lung maturity in neonates? What values are expected in neonatal respiratory distress syndrome (NRDS)?
The lecithin:sphingomyelin ratio in amniotic fluid; <1.5 for NRDS
• What vascular pathology is associated with persistently low oxygen tension due to neonatal respiratory distress syndrome?
Patent ductus arteriosus
• A newborn is cautiously administered oxygen by a neonatologist, who also performs serial eye exams. What is the physician worried about?
Retinopathy of prematurity (a side effect of therapeutic supplemental oxygen administration in newborns with NRDS)
• A newborn receives supplemental oxygen therapy for neonatal respiratory distress syndrome. This can lead to what three complications?
Retinopathy of prematurity, Intraventricular hemorrhage, and Bronchopulmonary dysplasia (RIB)
• What are three risk factors for neonatal respiratory distress syndrome?
Prematurity, maternal diabetes (due to elevated insulin), and cesarean delivery (due to decreased release of fetal glucocorticoids)
• A premature infant born to a diabetic mother exhibits intercostal retractions and appears hypoxic. What is the most likely diagnosis?
Neonatal respiratory distress syndrome
A newborn diagnosed with neonatal respiratory distress syndrome is at risk of what complications?
Metabolic acidosis, PDA, necrotizing enterocolitis