3.1 Introduction to lymphoproliferative disorders Flashcards Preview

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Flashcards in 3.1 Introduction to lymphoproliferative disorders Deck (18):
1

define lymphoma

heterogenous group of disorders originating from lymphoid cells in primary or secondary lymphoid organs

2

What are the primary lymphoid organs?

Bone marrow and thymus

3

What are the secondary lymphoid organs?

lymph nodes, spleen, mucosa associated lymphoid tissue

4

What is the more common lymphoma?

Non-hodgkin

5

What age gets Non-hodgkin and Hodgkin lymphoma?

Non: incidence increases with age
Hodgkins: bimodal (young adults and elderly)

6

What is the characterising factors of Hodgkin lymphoma?

Reed Sternberg cells

7

What are the pre germinal centre lymphomas?

Mantle cell
Chronic lymphocytic leukaemia
Small lymphocytic leukaemia

8

What are the germinal centre lymphomas?

Burkitt
Germinal centre B like Diffuse large B cell
Follicular lymphoma
Marginal zone

9

What are the post germinal centre lymphomas?

CLL, SLL
ABC diffuse large B cell
Multiple myeloma

10

What results from the chromosomal translocations
t(8;14) t(14;18) t(11;14)

Burkitt
B Cell Lymphoma 2
Mantle cell

11

What is the histological diagnosis of Hodgkin lymphoma?

Size: small vs large cell
Architecture: diffuse vs. follicular
Identifying features: Reed Sternberg cells (owl eyes)

12

Is lymphoma monoclonal or polyclonal?

Monoclonal

13

What is monoclonal?

All cells from one parent cell - all cells will express the same light chain (kappa of lambda)

Normal lymphocytes develop from different maturing B cells so will be polyclonal - monoclonality indicates lymphoma

14

Explain flow cytometry

Fluorescent dyes are attached to monoclonal antibodies and the patterns of expression will correlate to certain types of lymphomas - ONLY FOR B CELL LYMPHOMA

15

What markers will you see for pre germinal centre lymphoma?

CD5 positve

16

What markers will you see for post germinal centre lymphomas?

CD5 and 10 NEGATIVE

17

What will you have if it is CD10 positive?

Follicular lymphoma

18

What are the methods used to detect clonality?

Flow cytometry (B cells)
Immunohistochemistry
Molecular studies
TCR gene rearrangement (T cells)
Cytogenetics
FISH