Flashcards in 3.1 Introduction to lymphoproliferative disorders Deck (18):
heterogenous group of disorders originating from lymphoid cells in primary or secondary lymphoid organs
What are the primary lymphoid organs?
Bone marrow and thymus
What are the secondary lymphoid organs?
lymph nodes, spleen, mucosa associated lymphoid tissue
What is the more common lymphoma?
What age gets Non-hodgkin and Hodgkin lymphoma?
Non: incidence increases with age
Hodgkins: bimodal (young adults and elderly)
What is the characterising factors of Hodgkin lymphoma?
Reed Sternberg cells
What are the pre germinal centre lymphomas?
Chronic lymphocytic leukaemia
Small lymphocytic leukaemia
What are the germinal centre lymphomas?
Germinal centre B like Diffuse large B cell
What are the post germinal centre lymphomas?
ABC diffuse large B cell
What results from the chromosomal translocations
t(8;14) t(14;18) t(11;14)
B Cell Lymphoma 2
What is the histological diagnosis of Hodgkin lymphoma?
Size: small vs large cell
Architecture: diffuse vs. follicular
Identifying features: Reed Sternberg cells (owl eyes)
Is lymphoma monoclonal or polyclonal?
What is monoclonal?
All cells from one parent cell - all cells will express the same light chain (kappa of lambda)
Normal lymphocytes develop from different maturing B cells so will be polyclonal - monoclonality indicates lymphoma
Explain flow cytometry
Fluorescent dyes are attached to monoclonal antibodies and the patterns of expression will correlate to certain types of lymphomas - ONLY FOR B CELL LYMPHOMA
What markers will you see for pre germinal centre lymphoma?
What markers will you see for post germinal centre lymphomas?
CD5 and 10 NEGATIVE
What will you have if it is CD10 positive?