3.13 neoplasms

Question 0

Vimentin labels

Answer 0

Sarcomas

Question 1

Cytokeratin labels

Answer 1

Carcinomas

Question 2

Leukocyte common antigen labels

Answer 2

Lymphomas

Question 3

S100 labels

Answer 3

Melanomas

Question 4

GFAP labels

Answer 4

Gliomas

Question 5

Chromogranin / synaptophysin labels

Answer 5

Neuroendocrine tumors

Question 6

TTF1 tells you cancer is from

Answer 6

Lung

Thyroid

Question 7

Cytokeratin tells you tumor is from

Answer 7

Epithelial neoplasm

Question 8

How do you categorize lymphomas / leukemias

Answer 8

With flow cytometry

Question 9

Prognosis if have estrogen / progesterone receptors

Answer 9

Good because susceptible to tamoxifen

Question 10

Prognosis if have ERBB2 (her2neu) over expression

Answer 10

Poor, but can use trastuzumab

Question 11

Presence of KRAS can diagnose

Answer 11

Colon cancer

Question 12

CEA serum tumor marker for

Answer 12

Carcinoma

Question 13

Alpha fetoprotein serum tumor marker for

Answer 13

Hepatocellular carcinoma

Germ cell

Question 14

hCG serum tumor marker for

Answer 14

Trophoblastic cancer

Germ cell

Question 15

CA125 serum tumor marker for

Answer 15

Ovarian cancer

Question 16

CA19-9 serum tumor marker for

Answer 16

Pancreatic cancer

Colon cancer

Question 17

Ig serum tumor marker for

Answer 17

Plasma cell tumors

Question 18

How to determine non neoplastic vs malignant

Answer 18

B and T cell rearrangements

Question 19

If have oligodendriglioma, what would give a good prognosis

Answer 19

Loss of chromosome 1p and 19q (good response to chemo)

Question 20

How to detect minimal residual disease

Answer 20

RT PCR

Question 21

How to diagnose hereditary predisposition to cancer

Answer 21

Germ line mutation in tumor suppressor genes BRCA1&2, RET