33. Acromegaly Flashcards Preview

Endocrine > 33. Acromegaly > Flashcards

Flashcards in 33. Acromegaly Deck (16):
1

Acromeglay - definition

excess GH in adults

2

acromegaly - typically caused by

pituitary adenoma

3

gigantism - definition

increased linear bone growth

4

MCC of death in gigantism

heart hairlure

5

acromegaly - increased risk for

colorectal poly and cancer

6

acromegaly finding

1. large tongue with deep furrows
2. deep voice
3. large hands and feet
4. coarse facial features with aging
5. impaired gluocse intolerance ( insulin resistance )
6. frontal bossing

7

treatment

pituitary adenoma resection --> if not cured octeotide ( somatostatin analog) or pegvisomant ( Gh receptor anatagonist)

8

acromegaly diagnosis

1. pituitary masss seen in brain MRI
2. Increased IGF-1
3. failure to suppress serume GH followeing oral glucose test

9

pegvisomant - mechanism of action

GH receptor antagonist

10

octreotide - mechanism of action

somatostatin analog

11

acromegaly - tongue

large with deep forrows

12

acromegaly - voice

deep

13

acromegaly - face

coarse facial features

14

• How does excess growth hormone affect children and adults? What is the most common cause of death in both groups with this condition?

In children, increased linear bone growth and gigantism, and, in adults, acromegaly; heart failure is the most common cause of death

15

• A 50-year-old man has a big tongue w/ deep furrows, a deep voice, large hands/feet, and coarse facies. What diseases is he at high risk for?

Diabetes (acromegaly causes impaired glucose tolerance/insulin resistance), colorectal polyps and cancer

16

• A 50-year-old man recently had to resize his wedding ring, and his face seems coarser than usual. How do you diagnose his condition?

Acromegaly is diagnosed on the basis of high IGF-1, failure to suppress serum growth hormone after oral glucose tolerance test, pituitary mass on MRI