Flashcards in 34. Infections in immunodeficiency Deck (17):
Bacteria, viruses, Fungi / Parasites - decreased T celss
Viruses: CMV, EBV,JCV, VZV, chronice infenction with respiratory / GI viruses
fungi/parasites: Candida (local) PCP
Bacteria, viruses, Fungi / Parasites - decreased B celss
Virus enteroviral encephalitis, poliovirus (live vaccine contraindicated
fungi/ parasites: giardias (if no IgA)
Bacteria, viruses, Fungi / Parasites - decreased granulocytes
2. Burkholderia cepacia
3. Pseudomonas aeruginosa
Viruses : no
fungi / parasites: Candida (systemic), aspergillus, mucormycosis
Bacteria, viruses, Fungi / Parasites - low complement
bacteria --> encapsuled species with early complement deficiencies, Neisseria with late compoment deficiencies
Imunnodeficiency disorder with low INF - γ
2. AD hyper -IGE syndrome (Job syndrome)
Immunodeficiency disorder with cold abscess
AD hyper - IgE syndrome (job syndrome)
Immunodeficiency disorder with fewer and smaller platelets
Immunodeficiency disorder with delayed spearation of umpilical cord
Leukocyte adhesion deficiency
Immumodeficiency disorder with infiltrative lympho histiocytosis
• A patient with odynophagia and thrush is likely to have a deficiency of what type of immune cell?
T cells or granulocytes, as this patient has Candida esophagitis causing painful swallowing
What effect can a T-cell deficiency have on a bacterial infection?
Easy dissemination (sepsis)
• What is the difference between T-cell and B-cell deficiencies?
T-cell deficiencies tend to have recurrent viral/fungal infections, and B-cell deficiencies tend to have recurrent bacterial infections
A patient has a B-cell deficiency. What types of recurrent bacterial infections is he most susceptible to?
Encapsulated (Streptococcus pneumoniae,H.influenzae,N.meningitidis,E. coli,Salmonella,Klebsiella,group B Strep [SHiNE SKiS])
A child has a B-cell deficiency. What type of poliovirus vaccine is contraindicated?
Sabin oral (live), attenuated polio vaccine
A child with an immunodeficiency has greasy, foul-smelling stools. What immunodeficiency is likely?
B-cell deficiency with no immunoglobulin A (giardiasis), leading to lack of mucosal immunity
• A boy with C8 complement deficiency requires a vaccine. Which vaccine does he need? Which bacterium is he most susceptible to and why?
Meningococcal vaccine; Neisseria, as there is no formation of membrane attack complex (late complement deficiency)