34. Sarcoidosis Flashcards Preview

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Flashcards in 34. Sarcoidosis Deck (20)
1

σαρcoidosis is more common in ( epidemiology)

african - american females

2

sarcoidosis - characteristic ( histology)

widespreed noncaseating granulomas

3

origin of widespreed non caseating granulomas in sarcoidosis

immune mediated

4

sarcoidosis - CD4/CD8 ratio

elevated in BRONCHOALVEOLAR LAVAGE

5

sarcoidosis - " paraneoplastic:

1. elevated serum ACE
2. hypercalcemia

6

treatment

steroids

7

sarcoidosis - presentation

asymptomatic wxcept for enlarged lymph nodes

8

sarcoidosis- findings on CXR

bilateral adenopathy and coarse reticular opacitites

9

saexoidosis - chest CT

extensive hilar and mediastinal adenopathy

10

sarcoidosis is associated with

1. restrictive lung disease ( interstitial fibrosis)
2. erythema nodosum
3. Lupus pernio ( skin lesion o phase resembling Lupus)
4. Bell palsy
5. Uveitis
6. Hypercalcermia

11

sareitis coidosis - pathophysiology of hypercalcemia

increased 1-a hydroxylase activity of epitheliod histiocytes converts vitamin D to its active form

12

sarcoidosis - histology of granulomas

epitheloid granulomas containing microscopic Schaumann and asteroid bodies ( within Giant cells)

13

sarcoidosis - clinical manifestation on the eye

uveitis

14

MC presenting symptom of sarcoidosis

dyspnea or cough

15

• What population is most affected by sarcoidosis?

Black females

16

• What kind of process is sarcoidosis. What is the characteristic systemic pathologic finding?

Immune-mediated process; widespread noncaseating granulomas

17

• A patient with sarcoidosis develops progressive dyspnea on exertion. What kind of pattern would you expect to see on PFT?

A restrictive pattern, as patients with sarcoidosis can develop interstitial fibrosis

18

• What type of skin pathology is associated with sarcoidosis?

Erythema nodosum

19

• What two histopathologic findings are seen in the epithelioid granulomas of sarcoidosis?

Schaumann bodies and asteroid bodies

20

• A 29-year-old black woman has uveitis, lupus pernio, Bell palsy, and bilateral hilar adenopathy. How do you treat her?

Steroids (for sarcoidosis)

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