35. Stomach cancer Flashcards Preview

Gastrointestinal > 35. Stomach cancer > Flashcards

Flashcards in 35. Stomach cancer Deck (25)

gastric cancers - types ( and MC)

1. adenocarcinoma ( mC)
2. lymphoma
3. GI stromal tumor
4. carcinoid ( rate)


gastric cancer - behaviour , anemia

early aggresive local spread with node/ liver metastasis ---> oFTEN PRESENTS LATE


gastric cancer symptoms ( not signs)

present late, weight loss, early satiety


gastric cancer - signs

1. Leser Trelat sign
2. Virchow node
3. Krunkeberg tumor
4. Sister Mary Joseph nodule
5. acanthosis nigricans


Leser Trelat sign

explosive onset of multiple seborrheic keratosis


gastric cancer - Virchow node

involvement of left supravalvicular node by metastasis from stomach


Krunkenberg tumor

bilateral metastases to ovaries . Abundant mucin - secreting , signet ring cells


Sister Mary Joseph nodule

subcutaneous periumbilical metastasis


gastric adenocarcinoma - subtypes

1. intestinal
2. diffuse


gastric adenocarcinoma - interstinal vs diffuse according to H.pylori

1. intestinal ---> associated
2. diffuse --> not associated


gastric adenocarcinoma - causes of intestinal

1. H.pylori
2. dietery nitrosamines (smoked foods )
3. tobacco smoking
4. achloridria
5. chronic gastritis (intestinal metaplasia )
6. blood type A


gastric adenocarcinoma - apperance / location

looks like ulcer with raised margins commonly on lesser curvature


gastric adenocarcinoma - diffuse type - histological and gross apperance

signet ring cells (mucin filled cells with peripheral nuclei ) stomach wall grossly thickened (linnitis plastica ) due to desmoplasia


signet ring cells - apperance

mucin filled cells with peripheral nuclei


• What is the most common histologic subtype of stomach cancer?



• Where are intestinal stomach cancers most commonly located in the stomach: lesser curvature, greater curvature, fundus, or cardiac region?

Lesser curvature


• A patient with stomach cancer is at risk of metastasis to what organ?

The liver (this is the next downstream organ)


• Name at least three risk factors for stomach cancer.

Nitrosamines (from smoked foods), achlorhydria, chronic gastritis, smoking, H. pylori (the intestinal kind) infection


• What is meant when stomach cancer is termed linitis plastica?

Diffuse infiltrative cancer makes the stomach rigid


• A man has 1 month of fatigue, weight loss, and early satiety. If he has palpable lymph nodes (from metastases), where are they likely found?

Left-sided supraventricular nodes (also called Virchow nodes) (metastasis from stomach cancer classically spreads to these nodes)


• A woman has bilateral ovarian cancer with abundant mucus & signet ring cells. Could this cancer in fact be a metastasis?

Yes, as this could represent metastasis from the stomach to both ovaries (Krukenberg tumor)


• A patient has dark leathery patches on the nape of his neck and in the axillae. It is from malignancy. What might you see on his umbilicus?

One may see Sister Mary Joseph nodules (subcutaneous periumbilical metastasis) (this is acanthosis nigricans, suggesting stomach cancer)


• What is the histologic appearance of the Krukenberg tumor?

Metastatic gastric adenocarcinoma often has mucus-filled cells termed signet ring cells


• What is the Sister Mary Joseph nodule, and where is it located?

It is a metastasis of gastric cancer located in the subcutaneous periumbilical area


• A 65-year-old man has a growing periumbilical mass and abdominal fullness. What umbilical finding might be present on exam?

Sister Mary Joseph nodules (palpable and bulging due to metastases of various GI cancers)

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