39. Recombinant cytokines and clinical uses Flashcards Preview

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Flashcards in 39. Recombinant cytokines and clinical uses Deck (11):
1

Aldesleukin (il-2

Renal cell carcinoma,
metastic melanoma

2

Epoetin alfa (erythropoietin

anemias ( especialy in renal failure)

3

Filgastrim ( g-CSF)

recovery of bone marrow

4

Sagramostim (GM-CSF)

recovery of bone marrow

5

IFN-α

chronic hepatitis B and C , Kaposi sarcoma, malignant melanoma

6

IFN-β

Multiple sclerosis

7

IFN-γ

Chronic granulomatous disease

8

Romiplostum, eltrombopag (thrombopoietin receptro agonists)

Thrombocytopenia

9

Oprelvekin (IL-11)

Throbocytopenia

10

• A patient lacks NADPH oxidase and has recurrent bacterial infections. Which cytokine may be used for the treatment of his condition?

Interferon-γ (used in chronic "gammalomatous" disease [CGD])

11

Filgrastim, also known as ___, and sargramostim, also known as ___, may be used for the recovery of ___ .


Granulocyte colony–stimulating factor; granulocyte-macrophage colony–stimulating factor; bone marrow