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Flashcards in 4/2 micro Deck (168)
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1

Give HIV + mother what drug to prevent vertical transmission?

Zidovudine.

2

Where is pH the lowest in the nephron?

DCT & collecting duct

3

Hypertrphic cardiomyopathy
-what type of murmur?
-heard best where?

-Systolic due to LVOT obstruction.
-left sternal border.

4

Aortic regurg murmur
-heard best where?

left sternal border.

5

Aortic stenosis
-heard best where?

Aortic area
-right sternal border, 2nd intercostal space.

6

Uremia:
-PTT?
-PT?
-BT?
whats the problem here?

-qualitative platelet problem.
-BT increased, everything else is normal.

7

Pt. w/ESRD, dialysis catheter placed into IJ, and bleeding occurs around catheter site.
-whats the problem?
-abnormal test values?

ESRD => uremia => qualitative platelet problem.
-inc. BT.
-everything else is normal.

8

Ehlers Danlos
-defect is in which protein?

Type 3 collagen defect.

9

HMP shunt
-where does it occur?

cytoplasm

10

HMP shunt
-primary enzymes involved in non-oxidative steps?

transaldolase & transketolase.
*transketolase req. thiamine as cofactor.

11

All cells can synthesize ribose from which glycolysis intermediates w/help of transketolase & transaldolase?

F-6-P, G-3-P.
-they can do this even if oxidative reactions in HMP shunt not active in these cells.

12

Where is collagen triple helix formed?

ER

13

Which steps of collagen synth happen outside the cell?

Terminal propeptide removal, covalent cross links via lysyl oxidase.
*after propeptide removal, its called tropocollagen.

14

Lysyl oxidase
-what does it do?
-what cofactor does it need?

Cross links collagen molecules in extracellular space.
-copper.

15

Osteogenesis imperfecta
-which step of collagen synth is faulty?
-where does this step occur?

-formation of the triple helix.
-ER.

16

Which quadrant of your ass should you not give injections so you dont damage sup. gluteal nerve?

superomedial.

17

Which quadrants of your ass should you not inject so you dont damage sciatic n?

supermedial, inferomedial, inferolatera.
-basically everywhere except superolateral.

18

Rash + post-auricular lymphadenopathy:

Rubella

19

Congenital rubella
-Sxs:

PDA, cataracts, sensoneural deafness

20

Paramyxoviruses
-why do you see multinucleated cells?

-All contain surface F (fusion) protein, which causes respiratory epithelial cells to fuse and form multinucleated cells.

21

Palivizumab
-whats it do?
-whats it treat?

Palivizumab = mab against F protein.
-prevents pneumonia caused by RSV infection in premature infants.
*dont forget all paramyxoviridae have surface F-protein which causes resp. epithelial cells to fuse & form multinucleated cells.

22

Measles
-is it blanchable?

yes

23

measles
-do koplik spots occur before or after the rash?

Before

24

Measles pts
-which vitamin will you give them?

vitamin A.

25

Measles
-Sxs before the rash?
-mnemonic?

3 Cs
-cough, coryza, conjuncitivits
*& koplik spots.

26

Pregnant mother w/measles
-what can happen to baby?

No birth defects but can cause fetal death in 20% of cases.

27

Measles rash vs Rubella rash
-which includes the limbs?

Measles

28

Mumps
-Sxs?
-mnemonic?
*what other Sx?

Mumps makes your parotid glands and testes as
big as POM-poms.
-Parotitis, Orchitis, & aseptic Meningitis. Can cause
sterility (especially after puberty).
*pancreatitis.

29

Mumps
-one or both parotid glands affected?

-one or both.

30

Mumps pt. w/elevated serum lipase.
-whats the problem?

Mumps can cause pancreatitis.
-serum amylase & lipase will be inc.
-parotids & pancreas both contribute to elevated amylase.