Flashcards in 4 Cytoskeleton 1 Deck (29):
order microfilaments, intermediate filaments, and microtubules from smallest to largest
lamins, keratin, neurofilamin, vimentin, desmin, and GFAP are all examples of what?
intermediate filament subunits
actin is a subunit of what
tubulin is a subunit of what?
organelle transport is dependent on what filament?
which direction do kinesins move things?
orthograde (away from the nucleus)
which direction do dyneins move things?
retrogradetoward the nucleus
what forms the mitotic spindle apparatus?
what are axonemes? what is the array?
-specialized microtubule structures
-9 + 2 array
cilia and flagellar movement is dependent on what filament?
what are the role of basal bodies?
they are a microtubule structure that anchors axonemes - in particular, cilia
what is the motor for many MT functions?
what is the mechanism of taxol?
binds and stabilizes microtubules
what is the mechanism of colchicine and colcemid?
binds subunits and prevents their depolymerization
what is the mechnism of vinblastin and vincristine?
binds subunits and prevents their polymerization
what are the fundamental units of stress fibers?
what is the significance of stress fibers?
other the fact that the function was proposed at TUSM, they are found in endothelial cells lining large arteries to help support shear forces
what are three forms of actin?
beta, alpha, and nuclei
what is the function of beta actin?
helps cells move as it is localized to the migrating front
what filament is fundamental to cytokinesis?
phagocytosis is mediated by what filament?
leprosy, toxoplasmosis, and leischamniasis take advantage of what cellular process to infect the host?
microvili are composed of what filament?
what is the "dark side of actin"
it can be attacked by bacteria and viruses
how does listeria and vaccinia spread from cell to cell?
they hijack the actin microfilament assembly system
in general what is hereditary spherocytosis caused by?
defective membrane-cytoskeleton interactions
what is the basic structure of intermediate filaments?
desmosomes are a specialized (blank) structure?