4 Cytoskeleton 1 Flashcards Preview

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Flashcards in 4 Cytoskeleton 1 Deck (29):
1

order microfilaments, intermediate filaments, and microtubules from smallest to largest

-microfilaments
-intermediate filaments
-microtubules

2

lamins, keratin, neurofilamin, vimentin, desmin, and GFAP are all examples of what?

intermediate filament subunits

3

actin is a subunit of what

microfilament

4

tubulin is a subunit of what?

microtubules

5

organelle transport is dependent on what filament?

microtubules

6

which direction do kinesins move things?

orthograde (away from the nucleus)

7

which direction do dyneins move things?

retrogradetoward the nucleus

8

what forms the mitotic spindle apparatus?

microtubules

9

what are axonemes? what is the array?

-specialized microtubule structures
-9 + 2 array

10

cilia and flagellar movement is dependent on what filament?

microtubule

11

what are the role of basal bodies?

they are a microtubule structure that anchors axonemes - in particular, cilia

12

what is the motor for many MT functions?

dynein arms

13

what is the mechanism of taxol?

binds and stabilizes microtubules

14

what is the mechanism of colchicine and colcemid?

binds subunits and prevents their depolymerization

15

what is the mechnism of vinblastin and vincristine?

binds subunits and prevents their polymerization

16

what are the fundamental units of stress fibers?

actin

17

what is the significance of stress fibers?

other the fact that the function was proposed at TUSM, they are found in endothelial cells lining large arteries to help support shear forces

18

what are three forms of actin?

beta, alpha, and nuclei

19

what is the function of beta actin?

helps cells move as it is localized to the migrating front

20

what filament is fundamental to cytokinesis?

actin

21

phagocytosis is mediated by what filament?

actin

22

leprosy, toxoplasmosis, and leischamniasis take advantage of what cellular process to infect the host?

phagocytosis

23

microvili are composed of what filament?

actin

24

what is the "dark side of actin"

it can be attacked by bacteria and viruses

25

how does listeria and vaccinia spread from cell to cell?

they hijack the actin microfilament assembly system

26

in general what is hereditary spherocytosis caused by?

defective membrane-cytoskeleton interactions

27

what is the basic structure of intermediate filaments?

twisted rope

28

desmosomes are a specialized (blank) structure?

intermediate filament

29

hemidesmosomes are composed of what type of filament? what is their function?

-intermediate filament
-anchors skin cells to the basal lamina