4. multiple Sklerose Flashcards

(20 cards)

1
Q

(MS)

Epidemiologie

A

häufigste autoimmun vermittelte chronisch-entzündliche Erkrankung des ZNS

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2
Q

(MS)

Pathophysiologie (3)

A
  • Inflammation
  • Demyelinisierung
  • Neurodegeneration
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3
Q

(MS)

häufigste Symptome (6)

A
  1. Fatigue
  2. Gang- und Sensibilitätsstörungen
  3. Schmerzen und Muskelkämpfe
  4. Blasenstörung
  5. Depressionen
  6. Optikusneuritis
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4
Q

(MS)

häufigste Optikusneuritis

A

Retrobulbärneuritis

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5
Q

(MS)

Retrobulbärneuritis: Charakteristik

A

Zentralskotom und unauffällige Ophthalmoskopie

„Patient sieht nichts und Arzt sieht auch nichts“

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6
Q

(MS)

Befund

A

Lehrmitte-Zeichen

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7
Q

(MS)

Lehrmitte-Zeichen

A

positives Nackenbeugezeichen

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8
Q

(MS)

positives Nackenbeugezeichen

A

elektrisierende Missempfindungen entlang der Wirbelsäule

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9
Q

(MS)

Laboruntersuchung (2)

A

Blut- und Liquoruntersuchung

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10
Q

(MS)

obligate Blutuntersuchung (2)

A
  • Borrelien-Serologie
  • TPHA
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11
Q

(MS)

Bildgebung der Wahl

A

kranielle und spinale MRT

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12
Q

(MS)

MRT-Befund

A

multilokuläre Läsionen

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13
Q

(MS)

apparative Diagnostik der Wahl

A

neurophysiologische-

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14
Q

(MS)

neurophysiologische Diagnostik der Wahl

A

VEP

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15
Q

(MS)

VEP

A

Visuell Evozierte Potenziale

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16
Q

(MS)

VEP: Befund

A

Latenzverlängerungen infolge Demyelinisierung

17
Q

(MS)

Therapieplanung (2)

A
  • Schub-
  • verlaufsmodifizierende-
18
Q

(MS)

Schubtherapie der 1. Wahl

A

hochdosierte Glucocorticoide i.v. für 3-5 Tage

19
Q

(MS)

Schubtherapie der 2. Wahl

A

Plasmapherese

20
Q

(MS)

verlaufsmodifizierende Therapie: Möglichkeiten (2)

A
  • Immunmodulatoren
  • Immunsuppressiva