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Flashcards in 40. Therapeutic antibodies Deck (18):
1

Therapeutic antibodies for cancer (drug and target)

1. alemtuzumab --> CD52
2. bevacizumab --> VEGF
3. Cetuximab -- CD20
5. Trastuzumab (Herceptic) --> HER2/neu

2

Therapeutic antibodies for autoimmune disease therapy (drug and target)

1. Adalimumab --> Soluble TNF-α
2. Certolizumab --> Soluble TNF-α
3. Infliximab --> Soluble TNF-α
4. Eculizumab --> complement protein C5
5. Natalizumab --> a4 integrin

3

monoclonoal antibodies against TNF - α

1. Adalimumab --> Soluble TNF-α
2. Certolizumab --> Soluble TNF-α
3. Infliximab --> Soluble TNF-α

4

Monoclonal antibodies against TNF- α clinical use / SE

1. IBD
2.RA
3. Pdoriasis
4.Ankylosing spondylitings

SE
predispose to infenction, including reactiavation of latent TB

5

Entarcept - mechanism of action

fusion protein (receptor for TNF-α+ΙγΓ1 FC) produced by recombinant DNA ( A DECOY) --> Not antibody

6

Eculizuemab - target and clinical use

target : C5 protein
paroxysmal noctural hemoglobinuria

7

Natalizumab - mechanism of action

target α4-intergrin - WBC adhesion

8

Natalizumab- clinical use

1.MS
2. Crohn disease

9

natalizumab side effect

risk for PML in patients with JC virus

10

Abciximab - mechanism of action

monoclonal antibody against platelet glycoproteins IIB/IIa

11

Abciximab - clinical use

antiplatelet agent for prevention of ishemic complications in patients undergoing percutaneous coronary intervention

12

Denosumab - mechanism of action/ clinical use

monoclonal antibody agaisnsta RANKL --> inhibits osteoclast maturation (mimics osteoprotegerin)
clinical use : osteoporosis

13

Digoxin immun Fab-mechanism of action and clinical use

monoclonal antibody against Digoxin
antidote for digoxin toxicity

14

Ogmalizumab - mechanism of action and clinical use

monoclonal antibody against IgE --> prevent IgE binding to FCεRI
allergic asthma

15

Palivizumab -mechanism og /clinical useq

monoclonal antibody against RSV F protein
clinical use RSV prophylaxis for high risk infants

16

monoclonal antibodies agaisnt VEGF

1. Ranibizumab
2.Bevacizumab

17

monoclonal antibodies agaisnt VEGF -clinical use

1. Neovascular age-related macular degeneration
kai ta dio
2. colorectal cancer (Bevacizumab
3. renal cell carcinoma (Bevacizumab

18

monoclonal antibody against CD52 - deugs and clinical use

Alemtuzumab
1. CLL
2. MS