4.1 pharm plasma lipids

Question 0

Prevents reuptake of bile acids from intestine

Answer 0

Bile acid binding resins / sequestrants

Question 1

Inhibits HMG-CoA

Answer 1

Statins

Question 2

Inhibits uptake of dietary and biliary cholesterol from intestine

Answer 2

Cholesterol absorption blockers (ezetimibe)

Question 3

Inhibits cholesterol transport via NPC1L1

Answer 3

Cholesterol absorption blockers (ezetimibe)

Question 4

Decrease TG breakdown in adipose -> decrease FFA -> decrease VLDL production by liver

Answer 4

Niacin

Question 5

Activate nuclear receptor PPARα to affect LPL metabolism for TG metabolism

Answer 5

Fibrates

Question 6

Mainly increases HDL

Answer 6

Niacin

Question 7

Mainly decreases TG

Answer 7

Fibrates

Question 8

TG no change or slightly increase

Answer 8

Bile acid binding resins / sequestrants

Question 9

Can elevate LFTs

Answer 9

Statins
Cholesterol absorption blockers
Fibrates

Question 10

Can cause rhabdomyolysis

Answer 10

Statins

Question 11

Taste bad

Answer 11

Bile acid binding resins / sequestrants

Question 12

Decrease absorption of fat soluble vitamins

Answer 12

Bile acid binding resins / sequestrants

Question 13

CI if TG >400 mg/dl

Answer 13

Bile acid binding resins / sequestrants

Question 14

No effect of fat soluble vitamin uptake

Answer 14

Cholesterol absorption blockers

Question 15

Intense flushing reaction

Answer 15

Niacin

Question 16

Risk of gout

Answer 16

Niacin

Question 17

Risk of gallstones

Answer 17

Bile acid binding resins / sequestrants

Fibrates

Question 18

Can cause hyperglycemia

Answer 18

Niacin

Question 19

CI in pregnancy

Answer 19

Statins
Niacin
Fibrates

Question 20

CI if liver disease

Answer 20

Statins
Niacin
Fibrates

Question 21

CI in children

Answer 21

Fibrates

Question 22

CI if nursing

Answer 22

Statins

Question 23

Relative CI if diabetes

Answer 23

Niacin

Question 24

Relative CI if peptic ulcer

Answer 24

Niacin

Question 25

Relative CI if 3A4 drugs

Answer 25

Statins

Question 26

CI if renal disease

Answer 26

Fibrates

Question 27

Can cause GI problems

Answer 27

Bile acid binding resins / sequestrants