Flashcards in 43. H1 blockers Deck (17):
mechanism of action
REVERSIBLE inhibitors of H1 histamine receptors
H1 blockers - reversible or irreversible
H1 Blockers are divided to
1 st generation H1 blockers drugs
2nd generation H1 blockers- drugs
-ADINE + cetirizine
1st generation H1 blockers -used for
3. sleep aid
2nd generation H1 blockers -used for
1st generation H1 blockers -toxicity
2nd generation H1 blockers -toxicity
sedation ( much less than 1st generation)
1st vs 2nd generation H1 blockers according to sedation (why
2nd generation is Far LESS sedating than 1st generation because of decreased entry into CNS
• Are H1 blockers reversible or irreversible inhibitors?
• Name four second-generation H1 blockers.
Loratadine, fexofenadine, cetirizine, and desloratadine
• First-generation H1blockers usually end in ____, whereas second-generation H1blockers usually end in ____.
-en/-ine or -en/-ate, -adine
• A patient has motion sickness on a flight and would like to fall asleep. What class of medication would be useful for this patient?
H1 blockers (e.g., diphenhydramine), which are useful for allergies, motion sickness, and as sleep aids
• A patient takes chlorpheniramine for allergies. What side effects would you counsel the patient on?
Sedation, antimuscarinic symptoms, anti-α-adrenergic symptoms
• What is the clinical use of second-generation H1 blockers?