Flashcards in 4.3 Opioids Deck (19):
Describe the MOAs of methadone (3).
1) mu receptor agonist
2) NMDA receptor antagonist
3) Serotonin and NE reuptake inhibitor
Why is methadone substitution the preferred method of managing opioid withdrawl for addicted patients?
Long half life and less profound sedation and euphoria
What are the adverse effects of methadone? (3)
1) QT prolongation
2) Torsades de Pointes
What is the compound which has a longer half life than methadone and is FDA approved for detox clinics?
Which opioids are considered mild to moderate agonist? (6)
Which opioid is a mu agonist, has weaker analgesic properties than codeine, and is often used in combination with acetaminophen?
Which opioid has an increased risk of seizures and cardiac conduction abnormalities and should be avoided in the elderly?
What other drug, besides meperidine, may precipitate a serotonin syndrome?
What is the MOA of Tramadol?
-Weak mu agonist
-NE and Serotonin reuptake inhibitor
Which opioid is useful in neuropathic pain?
Which opioids are associated with increased risk of seizure?
Which drugs are mixed agonist-antagonist opioids? (4)
Which mixed agonist/antagonist are kappa agonist and mu antagonist or partial agonist? (4)
Which mixed agonist/antagonist is a Kappa agonist and a mu antagonist?
Which mixed agonist/antagonist is a partial mu agonist and a kappa antagonist?
Which mixed agonist/antagonist is it uncommon to have a psychotomimetic effect?
Which opioid antagonist is used in the treatment of acute opioid overdose?
Which opioid antagonist is used for opioid addiction and is also used to decrease craving for alcohol in chronic alcoholics?