4.3 Opioids Flashcards Preview

Pharmacology > 4.3 Opioids > Flashcards

Flashcards in 4.3 Opioids Deck (19):
1

Describe the MOAs of methadone (3).

1) mu receptor agonist
2) NMDA receptor antagonist
3) Serotonin and NE reuptake inhibitor

2

Why is methadone substitution the preferred method of managing opioid withdrawl for addicted patients?

Long half life and less profound sedation and euphoria

3

What are the adverse effects of methadone? (3)

1) QT prolongation
2) Torsades de Pointes
3) Death

4

What is the compound which has a longer half life than methadone and is FDA approved for detox clinics?

Levomethadyl Acetate

5

Which opioids are considered mild to moderate agonist? (6)

1) Codeine
2) Oxycodone
3) Hydrocodone
4) Dextropropoxyphene
5) Propoxyphene
6) Tramadol

6

Which opioid is a mu agonist, has weaker analgesic properties than codeine, and is often used in combination with acetaminophen?

Dextropropoxyphene

7

Which opioid has an increased risk of seizures and cardiac conduction abnormalities and should be avoided in the elderly?

Propoxyphene

8

What other drug, besides meperidine, may precipitate a serotonin syndrome?

Tramadol

9

What is the MOA of Tramadol?

-Weak mu agonist
-NE and Serotonin reuptake inhibitor

10

Which opioid is useful in neuropathic pain?

Tramadol

11

Which opioids are associated with increased risk of seizure?

- Tramadol
- Normeperidine
- Propoxyphene

12

Which drugs are mixed agonist-antagonist opioids? (4)

1) Pentaocine
2) Butorphanol
3) Nalbuphine
4) Buprenorphine

13

Which mixed agonist/antagonist are kappa agonist and mu antagonist or partial agonist? (4)

1) Pentazocine
2) Butorphanol

14

Which mixed agonist/antagonist is a Kappa agonist and a mu antagonist?

Nalbuphine

15

Which mixed agonist/antagonist is a partial mu agonist and a kappa antagonist?

Buprenorphine

16

Which mixed agonist/antagonist is it uncommon to have a psychotomimetic effect?

Buprenorphine

17

Which opioid antagonist is used in the treatment of acute opioid overdose?

Naloxone

18

Which opioid antagonist is used for opioid addiction and is also used to decrease craving for alcohol in chronic alcoholics?

Naltrexone

19

Which opioids are used as antimotility agents? (2)

1) Diphenoxylate
2) Loperamide