43. Zollinger-Ellison syndrome Flashcards Preview

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Flashcards in 43. Zollinger-Ellison syndrome Deck (13):
1

Zollinger - Ellison syndrome definition

gastrin - secretin tumor 9 gastinoma

2

Zolliνγερ - Ellison syndrome - area of tumor

1. pancreas
2. duodenum

3

Zollinger - Ellison syndrome is associated with

MEN 1

4

Zollinger ellison causes

acid hypersecretion --> recurrent ulcers in duodenum and jejunum

5

recurrent ulcers in

duodenum and jejunum

6

Zollinger - Ellison syndrome present with ( symptoms)

1. abdominal pain ( peptic ulcer disease, distal ulcers)
2. diarrhea ( malabsorption)

7

Zollinger - Ellison syndrome - diagnostic test

secretin stiumation test

8

normal action of secretin on gastrin

secretin normally inhibits gastrin release

9

Zollinger - Ellison syndrome - secretin stiumalation test ---> results

positive ---> gastrin levels remain elevated after administration of secretin

10

• Zollinger-Ellison syndrome is the result of a tumor that secretes what substance? Where is the tumor usually located?

Gastrin; the pancreas or duodenum

11

• A patient has failed several PPIs. On endoscopy, he has jejunal ulcers and thickened gastric rugae. What malignancy is possible?

Zollinger-Ellison syndrome caused by a gastrin-secreting tumor

12

• A patient has jejunal ulcers, diarrhea, and increased gastrin. What genetic syndrome is associated with this?

Multiple endocrine neoplasia (MEN) type I (gastrinoma of Zollinger-Ellison syndrome)

13

• A patient has abdominal pain, diarrhea, and recurrent duodenal ulcers. What test is positive in this syndrome?

Positive secretin stimulation test: high gastrin after administration of secretin (usually inhibits gastrin release) suggests gastrinoma