47. Pulmonary hypertension drugs Flashcards Preview

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Flashcards in 47. Pulmonary hypertension drugs Deck (25):
1

Pulmonary hypertension drugs - categories

1. endothelin receptor antagonists
2. PDE-5 inhibitors
3. Prostacyclin analogs

2

pulmonary hypertension drugs - categories and drugs

1. endothelin receptor antagonists ---> BOSENTAN
2. PDE-5 inhibitors --> SILDENAFIL
3. Prostacyclin analogs --> EPOPROSTENOL, ILOPROST

3

pulmonary hypertension drugs - endothelin receptor antagonists - drug and toxicitity

bosentan
hepatotoxicity

4

pulmonary hypertension drugs - endothelin receptor antagonists - monitor

monitor LFTs

5

pulmonary hypertension drugs - endothelin receptor antagonists - drug and mechanism

bosentan : competitively antagonize endothelin -1 receptros --> decreases pulmonary vascular resistance

6

pulmonary hypertension drugs - PDE-5 inhibitors - drugs

sildenafil (viagra

7

pulmonary hypertension drugs - PDE-5 inhibitors - mechanism of action

inhibit cGMP PDE5 and prolong vasodilatory effect of nitric oxide

8

pulmonary hypertension drugs - PDE-5 inhibitors - they also used for

erectile dysfunction

9

sildenafil - used for

1. pulmonary hypertension
2. erectile dysfunction

10

prostacyclin analogs side effects

1. flushing
2. jaw pain

11

prostacyclin analogs for pulmonary hypertension- drugs

1. epoprostenol
2. iloprost

12

prostacyclin analogs for pulmonary hypertension- mechanism of action

prostacyclins ( PGI2) with direct vasodilatory effects on pulmonary and systemi arterial vascular beds inhibit platelet aggregation

13

pulmonary hypertension treatment - categories

1. endothelin receptor antagonists ---> BOSENTAN
2. PDE-5 inhibitors --> SILDENAFIL
3. Prostacyclin analogs --> EPOPROSTENOL, ILOPROST

14

pulmonary hypertension treatment - drug with hepatotoxicity

bosental

15

hiv infenction pulmonary arterial hypertension

pulmonary arterial hypertension

16

type of pulmonary hypertension with poor prognosis

pulmonary arterial hypertension

17

obstructive sleep apnea - type of pulmonary hypertension

pJ due to lung disease or hypoxia

18

portal hypertension - type of pulmonary hypertension

pulmonary arterial hypertension

19

• Name the three types of drugs that are used for pulmonary hypertension.

Endothelin receptor antagonists, prostacyclin analogs, and PDE5 inhibitors

20

• Name a competitive endothelin receptor antagonist that is used to decrease pulmonary vascular resistance for pulmonary hypertension.

Bosentan

21

• A patient with COPD has a pulmonary artery pressure of 26 mmHg. He is prescribed an endothelin receptor antagonist. What must you monitor?

Monitor LFTs for hepatotoxic side effects (this patient has pulmonary hypertension from COPD, and the medication described is bosentan)

22

• What is the mechanism of action of sildenafil?

Inhibits cGMP PDE5 and prolongs nitric oxide vasodilatory effects

23

• A man with pulmonary hypertension and erectile dysfunction would benefit from which medication?

Sildenafil

24

• Name two prostacyclin analog medications that directly vasodilate pulmonary and systemic vascular beds for pulmonary hypertension.

Epoprostenol and iloprost

25

• A man with elevated pulmonary artery pressure is given a PGI2 analog that also works to inhibit platelet aggregation. Side effects?



Flushing and jaw pain (he has pulmonary artery hypertension, and the medication described is epoprostenol or iloprost)