48. Blistering skin disorders Flashcards Preview

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Flashcards in 48. Blistering skin disorders Deck (34)
1

Blistering skin disorders - types

1. pemphigus vulgaris
2. Bullous pemphigoid
3. Dermatitis herpetiformis
4. Erythema multiforme
5. Steven - JOhnson syndrome

2

pemphigus vulgaris - mechanism

autoimmune skin disorder with IgG antibody against desmoglein ( component of desmosomes ( stratum spinosum)

3

pemphigus bulgaris - apperance

Flaccid intraepidermal bullae caused by acantholysis
ORAL MUCOSA ALSO INVOLDED

4

pemphigus vulgaris - immunofluorescence

antibodies around epidermal cells in a reticular ( net like) pattern

5

Pemphigus vulgaris - sign

Nikolsky sign

6

Nikolsky sign +

separation of epidermis upon manual stroking of skin

7

pemphigus vulgaris - course

potentially fatal

8

Bulloud pemphigoid - mechanism

IgG antibody against hemidesmososme ( epiderma basement membrane)

9

Bullous pemphigoid - Nikolsky sign

negative

10

bullous pemphigoid - immunofluorescence

linear pattern at epidermal- dermal junction

11

bullous pemphigoid - apperance

tense blisters ( CONTAINING EOSINOPHILS) affect skin but spares oral mucosa

12

dermatitis herpetiformis - apperance

pruritic papules, vesicles and bullae ( often found on elbows)

13

dermatitis herpetiformis - pruritic papules, vesicles and bullae ( often found on

elbows

14

dermatitis herpetiformis - associated with

celiac disease

15

dermatitis herpetiformis - mechanism

deposits of IgA at tips of dermal papillae ( asssociated with celiac disease)

16

pemphigus vulgaris vs bullous pemphigoid - according course

pemphigus vulgaris --> potentially fatal
bullous pemphigoid - less severe

17

pemphigus vulgaris vs bullous pemphigoid - accronding to mechanism

pemphigus vulgaris ---> igG against desmoglein
bullus pemphigoid ---> IgG against hemidesmosomes

18

pemphigus vulgaris vs bullous pemphigoid - Nikolsky sign

pemphigus vulgaris ---> +
bullous pemphigoid ---> -

19

pemphigus vulgaris vs bulllous pemphigoid - immunofluorescense

pemphigus vulgaris --> reticular (net like)
bullous pemphigoid ---> linear pattern

20

Erythema multiforme is associated with

1. infenction
2. drugs
3. cancers
4. autoimmune diseases

21

Erythema multiforme - infenctions

1. Mycoplasma pneumoniaw
2. HSV

22

Erythema multiforme drugs

1. sulfa drugs
2. β-lactams
3. phenytoin

23

Erythema multiforme - presents with

multiple type of lessions - macules , papules , vessicles, target lesions

24

Erythema multiforme - target lesions

look like targets with multiple rings and dusky center showing epithelial disruption

25

Steven -Johnson syndrome -symptoms

1. feer
2. Bullae formation
3. necrosis
4. targetoid lesions may appear

26

Steven -Johnson syndrome - prognosis

high mortality rate

27

Steven -Johnson syndrome - skin manifestation

1. bullae formation
2. necrosis
3. sloughing of skin
4. targetoid lesions may appear

28

Steven -Johnson syndrome - typically involves

2 mucous membranes

29

Steven -Johnson syndrome - targtoid skin lesions may appear , as seen in

erythema multiforme

30

Steven - Johnson syndrome is usually assoxiated with ( is a result of )

adverse drug reaction

31

more severe form of Steven - Johnson syndrome

toxic epidermal necrolysis

32

toxic epidermal necrolysis - characteristic

more sever of Steven - Johnson syndrome
>30% of body surface

33

Steven - Johnson syndrome with >30% body surface

toxic epidermal necrolysis

34

Steven - Johnson syndrome with10-30% body surface

Steven - Johnson syndrome - toxic epidermal necrolysis

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