48. Hypothalamic/pituitary drugs Flashcards Preview

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Flashcards in 48. Hypothalamic/pituitary drugs Deck (11):
1

ADH antagonists
(conivaptan,
tolvaptan)





SIADH, block action of ADH at V2-receptor.

2

Desmopressin acetate

Central (not nephrogenic) DI.

3

GH

GH deficiency, Turner syndrome.

4

Oxytocin

Stimulates labor, uterine contractions, milk let-down; controls uterine hemorrhage.

5

Somatostatin
(octreotide)

Acromegaly, carcinoid syndrome, gastrinoma, glucagonoma, esophageal varices.

6

• What are two medical indications for use of growth hormone?

Growth hormone deficiency and Turner syndrome

7

• List five indications for the use of octreotide. Which hormone is it an analog of?

Gastrinoma, acromegaly, glucagonoma, carcinoid tumor, esophageal varices; somatostatin

8

• List three processes that can be stimulated with the use of exogenous oxytocin.

Labor, uterine contractions, milk let-down

9

• After delivery, a woman continues to have uterine bleeding. What normally endogenous substance can be given to stop the blood loss?

Oxytocin

10

• A woman is given desmopressin acetate. Can desmopressin be used in the treatment of nephrogenic diabetes insipidus (DI)?

No—desmopressin is an antidiuretic hormone analog that requires a renal response and therefore is effective only in central DI

11

• A drug blocks ADH at the V2 receptor. What condition is this drug used to treat? Name two drugs in this class.

SIADH; ADH antagonists include conivaptan, tolvaptan