What are the 5 invasive strains of Neisseria Meningitides?
A, B, C, Y and W-135
What is the tetravalent meningococcal vaccine introducing in order to gain immunity?
Polysaccharide (not protein) components of A, C, Y, and W-135
Why would someone without a spleen be more susceptible to microbes with polysaccaride antigens?
The spleen is the location of the Marginal zone B1 cells that respond to polysaccaride antigens.
Deficiency of terminal complement proteins increases risk especially to what kind of bacteria?
What is the immunopathology of Hereditary Angioedema (HAE)?
C1 inhibitor is nonfunctional or underexpressed, leading to uncontrolled complement activation. As a result, C2 and C4 is chronically low.
What is the name of the purified C1inh that can be given in cases of potentially lethal Hereditary Angioedema of the respiratory tract?
What is the immunopathology of Paroxysmal Nocturnal Hemoglobinuria?
What is the treatment?
Patients experience hemolysis of RBCs overnight, leading to hemoglobin in their urine in the morning. Pt’s RBCs and platelets have an increases sensitivity to complement lysis due to a defect in the Phosphatidylinositol Glycan Class A Gene (PIG-A) leading to a defect in the GPI anchor that is necessary for CD55 and CD59 presentation, which resists MAC.
EPO for blood loss, corticosteroids, and eculizumab.