50. Dextromethorphan Flashcards Preview

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Flashcards in 50. Dextromethorphan Deck (11):
1

use

antitussive

2

mechanism of action

antagonizes NMDA glutamine receptors

3

stucture

synthetic codein analog

4

antitode to overdose

naloxone

5

dextromethorpahn - side effects

Has mild opioid
effect when used in excess. N2.. Mild abuse potential. 3.May cause
serotonin syndrome if combined with other serotonergic agents.

6

Dextromethorphan combined with serteronergic agents

seretonin syndrome

7

seretonin syndrome

] Symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhea.[1][2] Body temperature can increase to greater than 41.1 °C (106.0 °F). Complications may include seizures and extensive muscle breakdown.[2]

8

• By what mechanism does dextromethorphan suppress cough?

It antagonizes NMDA glutamate receptors

9

• A patient with a cough overdoses on an NMDA glutamate receptor antagonist. What drug can be used to treat the overdose?

Naloxone (dextromethorphan can cause opioid-like effects

10

• Why does dextromethorphan have mild abuse potential?

If used in excess, it has a mild opioid effect

11

• A patient with depression takes a medication to suppress cough. She quickly becomes tachycardic & sweaty, & her fingers tremble. Diagnosis?

This is serotonin syndrome, seen when dextromethorphan is combined with another serotonergic agent such as certain antidepressants