50. Renal osteodystrophy Flashcards Preview

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Flashcards in 50. Renal osteodystrophy Deck (6):
1

Renal osteodystrophy ?

hypocalcemia, hyperphosphatemia and failure of vit D hydroxylation associated with chronic renla disease --> secondary hyperparathyroidism
ALSO hyperphosphatemia decreases serum Ca2+ by causing tissue calcification wheres low Vit D --> low interstinal Ca2+ absorption

2

Renal osteodystrophy causes ...(on bones)

subperiosteal thinning of bones

3

• Renal osteodystrophy arises as a result of the failure of what kidney function?

Production of active vitamin D, leading to hypocalcemia and a secondary increase in parathyroid hormone, resulting in bone loss

4

• A renal failure patient's bone scan shows subperiosteal bone thinning; labs: low vitamin D, hypocalcemia, and hyperphosphatemia. Diagnosis?

Renal osteodystrophy (secondary hyperparathyroidism)

5

• Renal osteodystrophy arises as a result of a failure of which step in vitamin D processing?

Vitamin D hydroxylation

6

• In renal osteodystrophy, two mechanisms contribute to low serum calcium levels. Identify these mechanisms.

Low vitamin D reduces calcium gut absorption and high phosphate sequesters serum calcium and leads to metastatic calcifications

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