5.13 pharm asthma Flashcards
(24 cards)
Can cause tremors
Terbutaline
Bitolterol
Albuterol
(All SABA)
Emergency
Inhaled SABA (albuterol)
Epinephrine if mucus plug
Conventional IV steroids (methylprednosolone)
Theophylline, aminophylline, ipatropium
Black box warning - increased mortality if used alone / not with glucocorticoids
LABA
- salmeterol
- formoterol
Increases cAMP
Beta agonists
Methyl xanthines
Blocks adenosine receptors
Methyl xanthines
- theophylline
- aminophylline
cAMP PDE inhibitor
Methyl xanthines
- theophylline
- aminophylline
Narrow margin of safety
Methyl xanthines
- theophylline
- aminophylline
Can cause arrhythmias
Methyl xanthines
- theophylline
- aminophylline
Can cause seizures
Methyl xanthines
- theophylline
- aminophylline
Causes dry mouth
Anticholinergics
- ipatropium
- tiotropium
Causes cough
Anticholinergics
- ipatropium
- tiotropium
Derivative of atropine
Anticholinergics
- ipatropium
- tioptopium
Cause oral candidiasis
Inhaled glucocorticoids
Anti-inflammatory
Glucocorticoids Crom (cromolyn sodium, nedocromil)
Bronchodilators
Beta agonists
Methyl xanthines
Anticholinergics
Re-ignition of Churg-Strauss syndrome
Switching from steroid to leukotriene modifying drugs
Leukotriene receptor antagonists
Zafirlukast
Montelukast
5’ lipoxygenase inhibitor
Zileuton
Blocks action of LT B4,C4,D4,E4
Zileuton
Blocks CysLT1
Zafirlukast
Montelukast
Anti-IgE
Omalizumab
Inhibits mast cell degranulation
Methyl xanthines - theophylline - aminophylline Cromolyn sodium, nedocromil IgE inhibitor - omalizumab
Alternative to inhaled steroids and LABA
Omalizumab (IgE inhibitor)
Churg-Strauss syndrome symptoms
Necrotizing vasculitis Skin rash Pulmonary inflammation Eosinophilia Heart failure
