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Flashcards in 5.4 Adrenals Deck (6)
0

Most important source of cholesterol

LDL

1

Formation of all corticosteroids starts with conversion of cholesterol to pregnenolone catalyzed by

SCC aka 20, 22 desmolase w/c is a rate-limiting enzyme and Major site of ACTH action

2

For cholesterol to be transported from cytosolic to inner mitochondrial membrane, a carrier protein called ________ is needed

Steroidogenic acute regulatory protein (StAR)

3

Important enzyme in synthesis of cortisol that is substantially found in zona fasciculata and reticularis

17-@hydroxylase

4

Type 1 HSD is a
A. Bidirectional enzyme
B. Unilateral enzyme

A. Bidirectional enzyme

Type 2 is a unidirectional enzyme

Note:
Type 1 present in liver, bone, muscle, adipose tissue, and gonads

Type 2 present in kidney and other target organs of aldosterone

5

Secreted in greatest amount
A. DHEA
B. DHEA- S
C. Testosterone

B. DHEA- S

Note:
Testosterone- most potent