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Flashcards in 56. Thiazide diuretics Deck (10):
1

Thiazide diuretics


Hydrochlorothiazide, chlorthalidone,
metolazone.

2

MECHANISM

Inhibit NaCl reabsorption in early DCT
---> decreased diluting capacity of nephron. Decreased Ca2+
excretion.
HyperGLUC.

3

CLINICAL USE

Hypertension, HF, idiopathic hypercalciuria,
nephrogenic diabetes insipidus, osteoporosis.

4

ADVERSE EFFECTS

Hypokalemic metabolic alkalosis,
hyponatremia, hyperGlycemia,
hyperLipidemia, hyperUricemia,
hyperCalcemia.
Sulfa allergy

hyperGLUC

5

• Serum levels of which substances are increased as a result of the effects of thiazide diuretics?

Glucose (hyperGlycemia), lipids (hyperLipidemia), uric acid (hyperUricemia), and calcium (hyperCalcemia) (hyperGLUC)

6

• ____ (Loop/Thiazide) diuretics increase calcium excretion; ____ (loop/thiazide) diuretics decreases it.

Loop; thiazide

7

• Name some clinical uses of thiazide diuretics.

To treat hypertension, congestive heart failure, idiopathic hypercalciuria, nephrogenic diabetes insipidus

8

• What acid-base abnormality is associated with thiazide diuretic use?

Hypokalemic metabolic alkalosis

9

• A patient of yours with a history of gout and diabetes wants to start hydrochlorothiazide for hypertension. You refuse. Why?

Hydrochlorothiazide increases levels of both uric acid and glucose, which may worsen the patient's gout and diabetes, respectively

10

• A patient of yours starts chlorthalidone for hypertension and notes fewer kidney stone attacks. Why might this be happening?

Hydrochlorothiazide increases DCT reabsorption of calcium, which reduces the likelihood of calcium-containing stones in the urine

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