57. K+-sparing diuretics Flashcards Preview

Renal > 57. K+-sparing diuretics > Flashcards

Flashcards in 57. K+-sparing diuretics Deck (9):
1

Potassium-sparing
diuretics




Spironolactone and eplerenone; Triamterene,
and Amiloride.

The K+ STAys.

2

MECHANISM

Spironolactone and eplerenone are competitive
aldosterone receptor antagonists in cortical
collecting tubule. Triamterene and amiloride
act at the same part of the tubule by blocking
Na+ channels in the cortical collecting tubule.

3

CLINICAL USE

Hyperaldosteronism, K+ depletion, HF,

4

CLINICAL USE hepatic
ascites

spirolactone

5

CLINICAL USE nephrogenic DI

(amiloride).

6

ADVERSE EFFECTS

Hyperkalemia (can lead to arrhythmias),
endocrine effects with spironolactone (eg,
gynecomastia, antiandrogen effects).

7

• What are the mechanisms of action of spironolactone and eplerenone? What about triamterene and amiloride?

Spironolactone and eplerenone competitively antagonize the aldosterone receptor; triamterene and amiloride block luminal sodium channels

8

• A patient begins taking a second diuretic to offset the effect of furosemide. What part of the nephron does this second diuretic act upon?

The cortical collecting tubule (this is likely a potassium-sparing diuretic)

9

• Your patient is starting on a potassium-sparing diuretic and is worried about side effects. What do you tell him?

Side effects include hyperkalemia (leading to arrhythmias) and endocrine effects with spironolactone (gynecomastia and antiandrogen effects)

Decks in Renal Class (61):