Flashcards in 57. Reye syndrome Deck (13)
Re adye syndrome ?
Rare, often fatal childhood hepatic encephalopathy
Reye syndrome - findings / symptoms
1. mitochondrial abnormalities
2. fatty liver ( microvesicular fatty change)
due to / mechanism
viral infenction ( esp VZV anf infl B ) that has been treated with aspirin. Mechanism : aspirin metabolites decrease β- oxidation by reversible inhibition of mit enzymes
esp VZV and influenza B
aspirin in children ?
avoid ---> except Kawasaki
• A 5-year-old boy with seasonal flu is given aspirin for his fever and develops altered mental status and elevated LFTs. Diagnosis?
• What pathologic liver change is associated with Reye syndrome?
Microvesicular fatty changes and, later on, hepatomegaly
• A 7-year-old girl is thought to have Reye syndrome. What metabolic disturbance do you check for (it shows up on a basic metabolic panel)?
• A mother brings in her son for lethargy and vomiting. A week ago he had a viral infection treated with a drug. What was he likely given?
Aspirin or salicylates (the boy likely developed Reye syndrome, which can occur in children with viral infections treated with aspirin)
• List two viral infections that are strongly associated with Reye syndrome.
Varicella zoster virus, influenza B
• A mother asks if she can give her 4-year-old son aspirin for his fever of 101°F. What drug would you recommend instead?
Acetaminophen or ibuprofen
• How does aspirin cause Reye syndrome in young infants?
Aspirin metabolites reversibly inhibit mitochondrial enzymes and cause a decrease in β-oxidation