57. Reye syndrome Flashcards Preview

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Flashcards in 57. Reye syndrome Deck (13)

Re adye syndrome ?

Rare, often fatal childhood hepatic encephalopathy


Reye syndrome - findings / symptoms

1. mitochondrial abnormalities
2. fatty liver ( microvesicular fatty change)
3. hypohlycemia
4. vomiting
5. hepatomegaly'
6. coma


due to / mechanism

viral infenction ( esp VZV anf infl B ) that has been treated with aspirin. Mechanism : aspirin metabolites decrease β- oxidation by reversible inhibition of mit enzymes


virus ?

esp VZV and influenza B


aspirin in children ?

avoid ---> except Kawasaki


• A 5-year-old boy with seasonal flu is given aspirin for his fever and develops altered mental status and elevated LFTs. Diagnosis?

Reye syndrome


• What pathologic liver change is associated with Reye syndrome?

Microvesicular fatty changes and, later on, hepatomegaly


• A 7-year-old girl is thought to have Reye syndrome. What metabolic disturbance do you check for (it shows up on a basic metabolic panel)?



• A mother brings in her son for lethargy and vomiting. A week ago he had a viral infection treated with a drug. What was he likely given?

Aspirin or salicylates (the boy likely developed Reye syndrome, which can occur in children with viral infections treated with aspirin)


• List two viral infections that are strongly associated with Reye syndrome.

Varicella zoster virus, influenza B


• A mother asks if she can give her 4-year-old son aspirin for his fever of 101°F. What drug would you recommend instead?

Acetaminophen or ibuprofen


• How does aspirin cause Reye syndrome in young infants?

Aspirin metabolites reversibly inhibit mitochondrial enzymes and cause a decrease in β-oxidation


• There is one fever syndrome for which children are actually encouraged to take aspirin. What is it? Why?

Kawasaki disease; aspirin is needed to treat inflammation and prevent clots from forming

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