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Flashcards in 60. Angiotensin II receptor blockers Deck (8):
1

Angiotensin II receptor
blockers



Losartan, candesartan, valsartan.

2

MECHANISM

Selectively block binding of angiotensin II to AT1 receptor. Effects similar to ACE inhibitors, but
ARBs do not increase bradykinin.

3

CLINICAL USE

Hypertension, HF, proteinuria, or diabetic nephropathy with intolerance to ACE inhibitors (eg,
cough, angioedema).

4

ADVERSE EFFECTS

Hyperkalemia, decreased GFR, hypotension; teratogen
.

5

• A patient is switched from an ACE inhibitor to an ARB because of side effects. Why is the ARB mechanism better for this patient?

ACE inhibitors can lead to angioedema by increasing bradykinin (ARBs do not inhibit ACE and therefore do not increase bradykinin)

6

• A patient switches from an ACE inhibitor to an ARB. What do you expect the levels of renin, angiotensin I and angiotensin II (AT II) to be?

Renin and angiotensin I remain high, but now AT II is high as a result of blockage of AT2 receptor instead of ACE

7

• What are the side effects of ARBs?

Hyperkalemia, decreased renal function, hypotension; teratogenicity

8

• Name some clinical indications for ARBs.

Hypertension, HF, proteinuria, or diabetic nephropathy, generally with intolerance to ACE inhibitors (e.g., cough, angioedema)

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