61. Aliskiren Flashcards Preview

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Flashcards in 61. Aliskiren Deck (7):
1

MECHANISM

Direct renin inhibitor, blocks conversion of angiotensinogen to angiotensin I.

2

CLINICAL USE

Hypertension.

3


ADVERSE EFFECTS

Hyperkalemia, Decreased GFR, hypotension. Relatively contraindicated in patients already taking ACE
inhibitors or ARBs.

4

• A patient has tried ACE inhibitors, ARBs, and spironolactone. What other medication would you suggest that acts on the RAAS?

A direct renin inhibitor such as aliskiren

5

• A patient was recently switched from an ACE inhibitor to aliskiren. What change would you expect in the RAAS?

Aliskiren is a direct renin inhibitor, so angiotensinogen would increase, whereas angiotensin I would decrease

6

• A diabetic man was recently switched to an ARB from an ACE inhibitor. His blood pressure is still not ideal. Should you consider aliskiren?

No, it is contraindicated in diabetic patients already taking an ACE inhibitor or ARB

7

• What are the side effects of aliskiren?

Hyperkalemia, decreased renal function, hypotension (also contraindicated in diabetics taking ACE inhibitors or ARBs)

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