61. Hepatocellular carcinoma/hepatoma Flashcards Preview

Gastrointestinal > 61. Hepatocellular carcinoma/hepatoma > Flashcards

Flashcards in 61. Hepatocellular carcinoma/hepatoma Deck (14):
1

MC liver tumor

metastasis

2

MC primary liver malignant tumor in adults

Hepatocellular carcinoma ( hepatoma )

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causes of hepatocellular carcinoma

1. HBV (+/- cirrhosis)
2. all causes of cirrhosis
3. specific carcinogens ( eg. aflatoxin from aspergillus)

4

a complication og hepatocellular carcinoma ( may lead to...)
Hepatocellular carcinoma spreads ...

- Budd CHiari syndrome
- hematogenously

5

hepatocellular carcinoma - diagnosis

1. increased a- fetoprotein
2. US or contract CT / MRI
3. biopsy

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hepatocellular carcinoma - symptoms/ findings

1. jaundice
2. tender hepatomegaly
3. ascites
4. polyethemia
5. anorexia

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paraneoplastic

erythropoietin

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• What two viral diseases are associated with an increased incidence of hepatocellular carcinoma?

Hepatitis B and C

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• Excessive exposure to what two substances is associated with an increased incidence of hepatocellular carcinoma?

Alcohol (alcoholic cirrhosis) and carcinogens such as aflatoxin

10

• A 47-y/o man's friend is diagnosed with hepatocellular carcinoma. The man asks what factors might increase his risk for this disease.

Hepatitis B and C, Wilson disease, hemochromatosis, α1-antitrypsin deficiency, alcoholic cirrhosis, carcinogens (e.g., aflatoxins)

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• A 52-y/o man comes in with RUQ abdominal pain and is convinced that this could be liver cancer. What signs/symptoms could you check for?

Jaundice, tender hepatomegaly, ascites, polycythemia, anorexia

12

• A doctor suspects hepatocellular carcinoma in a patient. She orders what lab, expecting it to be elevated?

α-fetoprotein, because it is elevated in hepatocellular carcinoma

13

• How might a hepatocellular carcinoma predispose a patient to Budd-Chiari syndrome?

Via polycythemia (a hypercoagulable state leading to thrombosis in the hepatic vein) or by direct compression of the hepatic vein

14

• A woman with hemochromatosis develops jaundice and ascites and is found to have elevated serum α-fetoprotein levels. What is the diagnosis?

Hepatocellular carcinoma

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