Flashcards in 61. Hepatocellular carcinoma/hepatoma Deck (14):
MC liver tumor
MC primary liver malignant tumor in adults
Hepatocellular carcinoma ( hepatoma )
causes of hepatocellular carcinoma
1. HBV (+/- cirrhosis)
2. all causes of cirrhosis
3. specific carcinogens ( eg. aflatoxin from aspergillus)
a complication og hepatocellular carcinoma ( may lead to...)
Hepatocellular carcinoma spreads ...
- Budd CHiari syndrome
hepatocellular carcinoma - diagnosis
1. increased a- fetoprotein
2. US or contract CT / MRI
hepatocellular carcinoma - symptoms/ findings
2. tender hepatomegaly
• What two viral diseases are associated with an increased incidence of hepatocellular carcinoma?
Hepatitis B and C
• Excessive exposure to what two substances is associated with an increased incidence of hepatocellular carcinoma?
Alcohol (alcoholic cirrhosis) and carcinogens such as aflatoxin
• A 47-y/o man's friend is diagnosed with hepatocellular carcinoma. The man asks what factors might increase his risk for this disease.
Hepatitis B and C, Wilson disease, hemochromatosis, α1-antitrypsin deficiency, alcoholic cirrhosis, carcinogens (e.g., aflatoxins)
• A 52-y/o man comes in with RUQ abdominal pain and is convinced that this could be liver cancer. What signs/symptoms could you check for?
Jaundice, tender hepatomegaly, ascites, polycythemia, anorexia
• A doctor suspects hepatocellular carcinoma in a patient. She orders what lab, expecting it to be elevated?
α-fetoprotein, because it is elevated in hepatocellular carcinoma
• How might a hepatocellular carcinoma predispose a patient to Budd-Chiari syndrome?
Via polycythemia (a hypercoagulable state leading to thrombosis in the hepatic vein) or by direct compression of the hepatic vein