6.10 antidep pharm

Question 0

Sertraline

Answer 0

Med half life SSRI

Question 1

Fluoxetine

Answer 1

Long half life SSRI

Question 2

Citalopram

Answer 2

Medium half life SSRI

Question 3

Escitalopram

Answer 3

Medium half life SSRI

Question 4

Paroxetine

Answer 4

Short half life SSRI

Question 5

Fluvoxamine

Answer 5

Short half life SSRI

Question 6

Venlafaxine/desvenlafaxine

Answer 6

SNRI

Question 7

Duloxetine

Answer 7

SNRI

Question 8

Milnacipran / levomilnacipran

Answer 8

SNRI

Question 9

Phenelzine

Answer 9

MAOI

Question 10

Tranylcypramine

Answer 10

MAOI

Question 11

Selegiline

Answer 11

MAOI

Question 12

Desipramine

Answer 12

TCA secondary amine

Question 13

Nortriptyline

Answer 13

TCA secondary amine

Question 14

Amitryptyline

Answer 14

TCA tertiary amine

Question 15

Imipramine

Answer 15

TCA tertiary amine

Question 16

Clomipramine

Answer 16

TCA tertiary amine

Question 17

Trazodone

Answer 17

SARI (serotonin antagonist and reuptake inhibitor)

Question 18

Nefazodone

Answer 18

SARI (serotonin antagonist and reuptake inhibitor)

Question 19

Vilazodone

Answer 19

Unique MOA

Question 20

Bupropion

Answer 20

Unique MOA

Question 21

Mirtazapine

Answer 21

NaSSA (noradrenergic and specific serotonin antidepressant)

Question 22

Drugs least likely to cause bipolar to switch to mania

Answer 22

SSRIs

Bupropion

Question 23

NT goal of antidep

Answer 23

Increase serotonin and NE concentration ant postsynaptic receptors

Question 24

Vilazodone general mechanism

Answer 24

Reuptake inhibition

Question 25

Bupropion general mechanism

Answer 25

Reuptake inhibition

Question 26

Mirtazapine general mechanism

Answer 26

Receptor blockade

Question 27

Trazodone general mechanism

Answer 27

Receptor blockade

Question 28

Nefazadone general mechanism

Answer 28

Receptor blockade

Question 29

Used for depression and insomnia

Answer 29

Trazodone

Question 30

Used primarily for OCD

Answer 30

Fluvoxamine

Question 31

Active metabolite of fluoxetine

Answer 31

Norfluoxetine

Question 32

Only SSRI that needs BID

Answer 32

Fluvoxamine

Question 33

SSRIs with low drug interaction risk because hits many CYP P450s

Answer 33

Sertraline Citalopram Escitalopram

Question 34

SSRIs with high drug interaction risk b/c hits only one CYP P450

Answer 34

Fluvoxamine Paroxetine Fluoxetine

Question 35

Important SSRI drug interactions

Answer 35

``` Clozapine Fentanyl Hydrocodone Methadone Tamoxifen Tramadol ```

Question 36

Sexual ADRs that do not resolve - caused by what meds

Answer 36

SSRIs

Question 37

MAOIs should never be used with

Answer 37

SSRIs

Question 38

Serotonin syndrome can occur with what drugs

Answer 38

SSRIs | MAOIs

Question 39

Potent 2D6 inhibitor

Answer 39

Fluoxetine | Paroxetine

Question 40

Black box warning for suicide risk

Answer 40

SSRIs

Question 41

Potent 1A2 inhibitor

Answer 41

Fluvoxamine

Question 42

Can be used for fibromyagia

Answer 42

Duloxetine | Milnacipran

Question 43

What is also used for Parkinson's

Answer 43

Selegiline

Question 44

Can get hypertensive crisis with tyramine

Answer 44

MAOIs

Question 45

MAO-A location

Answer 45

brain and intestine

Question 46

MAO-B location

Answer 46

brain and platelets

Question 47

MAO-A substrates

Answer 47

``` Epi NE DA 5-HT tyramine ```

Question 48

MAO-B substrates

Answer 48

beta-phenylethylamine DA tyramine

Question 49

fatal respiratory depression and arrhythmia

Answer 49

TCAs

Question 50

Can cause hypotension

Answer 50

TCAs

Question 51

Causes hepatotoxicity

Answer 51

Nefazodone

Question 52

Strong 3A4 inhibitor

Answer 52

Nefazodone

Question 53

Also used for smoking cessation

Answer 53

Bupropion

Question 54

Risk of seizures

Answer 54

Bupropion

Question 55

Has active metabolite similar to amphetamine

Answer 55

Bupropion

Question 56

Antagonist of alpha2-AR

Answer 56

Mirtazapine

Question 57

Causes sedation and weight gain

Answer 57

Mirtazapine | TCAs

Question 58

Used in combination w/ SSRI to treat SSRI-induced sexual dysfunction

Answer 58

Bupropion

Question 59

Treat Serotonin Syndrome

Answer 59

Benzo and 5-HT2A antagonist (cyproheptadine)

Question 60

Cyproheptadine is used for

Answer 60

Treating serotonin syndrome

Question 61

Dantrolene used for

Answer 61

Treating serotonin syndrome (is a neuromuscular blocker)

Question 62

Serotonin syndrome sxs

Answer 62

``` autonomic instability rigidity fever stupor death ```

Question 63

Has pressor effects

Answer 63

SNRIs (from norepinephrine)

Question 64

A hypertensive crisis from MAOI and tyramine causes

Answer 64

intracerebral hemorrhage

Question 65

Too much tyramine with MAOI causes

Answer 65

Hypertensive crisis

Question 66

SARI receptors

Answer 66

Antagonism of 5HT2A, 5HT1A, alpha1-AR

Question 67

Can cause agitation, anxiety, restlessness

Answer 67

Bupropion