69. Pathologic pigmentation caused by melanin, lipofuscin, and ceroid Flashcards
(11 cards)
1
Q
Melanin, lipofuscin and ceroid are grouped as…
A
Autochton pigments
Anhaemoglobinogenous pigments
2
Q
Reaction of forming melanin
A
- Tyrosinase: Converts tyrosine → melanin
- Does **not contain iron **
3
Q
Melanin
pigment:
produced by :
stored by:
regulates by :
A
pigment: brownish-black
produced by : melanocyte
stored by: melanophage
regulates by: hypophysis
4
Q
Where in the body is melanin located (physiologically)
A
- Skin
- Epidermis & corium
- During prengnancy
- Nipples, face, mid-line of belly
- Eye
- Ganglion cells
- Leptomenings
- Oral cavity
- Mammary gland - Berkshire pigs
- Serous membrane - Reptiles & birds
5
Q
Give the three variations of abnormal pigmentation
A
- Hyperpigmentatio
- Hypopigmentatio
- Albinismus
6
Q
Lipofuscin
Pigment:
contain :
formed:
A
Pigment:Golden-brown
contain :Proteins & lipids, no iron
formed: lysosomes of ageing cells
7
Q
Lipofuscin: Location
A
- Liver
- Kidney tubule
- Adrenal gland
- Choroid plexus
- Muscle cells
8
Q
Lipofuscin: Pathogenic conditions
A
- Brown bowel syndrome
- Neuronal ceroid lipofuscinosis
9
Q
Ceroid
Pigment:
Produced in :
A
Pigment: yellow, Lipogenous
Produced in:macrophages and hepatocytes
10
Q
Disease in Ceroid
A
Yellow fat disease:→ Accumulation of ceroids in fatty tissues
11
Q
Ceroid
found in:
A
- Lipocytes
- Macrophages
- MPS-cells
- Yellow adipose
