Flashcards in 76. **Acid suppression therapy Deck (12):
• Proton pump inhibitors work on pumps that exchange which two ions?
Hydrogen and potassium
• H2 blockers work on which stomach cell type?
• Muscarinic antagonists work on which two cell types in the stomach?
Enterochromaffin-like cells (with M1 receptors) and parietal cells (with M3 receptors)
• Why are misoprostol, sucralfate, and bismuth useful in treating gastric ulcers?
These drugs have a protective effect on the mucosa underlying the ulcers
• Where does somatostatin act?
Somatostatin acts on enterochromaffin-like cells via ST2 receptors
• A surgeon damages the vagus nerve while operating. What type of GI therapy would be directly impacted?
Muscarinic antagonists, because the vagus nerve stimulates the M1 and M3 receptors
• A man has been taking an antacid for GERD pain. What is the mechanism for this drug and where does it target?
Antacids work in the stomach lumen and block the secretion of acid, or H+
• What type of cell in the antrum is stimulated by food? What hormone is stimulated by food to promote gastric acid secretion?
G cell; gastrin
• If a patient is deficient in gastrin, which cells and receptors will be understimulated in the fundus?
Parietal cells and ECLs (both have G [CCK-B] receptors that are stimulated by gastrin)
• A patient has a gastric ulcer causing severe pain. Name at least two medications can be given to help with ulcer healing?
Misoprostol, sucralfate, bismuth
• You study stomach gastrin activity. You administer food to rats and take several biopsies. Which stomach area will show the most activity?