8 - Malignant disease

Question 1

Tacrolimous and cicloporin are both ……

name a significant sideeffect of each

Answer 1

calcineurin inhibitors - for preventing transplant rejection MAINTAIN BRAND

ciclopsorin - nephrotoxic & skin conditions
tacrolimus - glucose metabolism disturbance

Question 2

some risks of MABs (antilymphocyte) 3

Answer 2

cytokine release - tumour lysis syndrome
and infustion related reactions
progressive multifocal leucoencephalopathy

Question 3

what mab is associated with oesteonecrosis of the jaw

Answer 3

bevacizumab

Question 4

what mab is assiciated with kerititis and ulcerative kerititis

Answer 4

cetuximab (this acts on epidermal GROWTH factor)

Question 5

mab for EDFR in non mutated RAS cancers associated with warnings about

• severe skin reactions
• keritits and ulcerative keritis

Answer 5

panitumumab