Flashcards in 80. Misoprostol Deck (10)
Misoprostol - Mechanism
A PGE1 analog. Increased production and secretion of gastric mucous barrier, decreased acid production.
Misoprostol - Clinical use
Prevention of NSAID-induced peptic ulcers (NSAIDs block PGE1 production); maintenance of a
PDA. Also used off-label for induction of labor (ripens cervix).
Misoprostol - Adverse effects
Diarrhea. Contraindicated in women of childbearing potential (abortifacient).
• Misoprostol is a ____ analog.
• Misoprostol increases the production and secretion of the ____ barrier and decreases the production of ____.
Gastric mucous; acid
• A patient with rheumatoid arthritis starts misoprostol after being intolerant to her prior treatment. What was the complication?
Peptic ulcers induced by NSAIDs (misoprostol increases gastric mucous production and decreases acid production)
• A neonate is noted to be cyanotic on the third day of life. What medication should be ordered immediately?
Misoprostol, which maintains a patent ductus arteriosus, allowing pulmonary and systemic circulations to mix in cases of heart disease
• A woman is given misoprostol at 42 weeks' gestation. Why?
To induce labor
• Within what population is misoprostol contraindicated?
Women of childbearing potential (it is an abortifacient)