8.1. Mulit-System Autoimmune Disease - Connective Tissue Diseases Flashcards Preview

3rd Year - MSK Diseases > 8.1. Mulit-System Autoimmune Disease - Connective Tissue Diseases > Flashcards

Flashcards in 8.1. Mulit-System Autoimmune Disease - Connective Tissue Diseases Deck (18):
1

What are the 2 broad categories of Mulit-System Autoimmune Disease?

1. Connective Tissue Diseases
2. Systemic Vasculitis Disease

2

What are the common Connective Tissue Mulit-System Autoimmune Disease?

1. Systemic Lupus Erythematous (SLE)
2. Scleroderma
3. Sjogren's Syndrome
4. Auto-Immune Myositis
5. Mixed Connective Tissue Disease

3

What are common Systemic Vasculitis Mulit-System Autoimmune Disease?

1. Giant Cell Arteritis
2. Granulomatosis Polyangiitis (Wegner's Granulomatosis)
3. Microscopic Polyangiitis
4. Eosinophilic Granulomatosis Polyangiitis (Churg-Strauss Granulomatosis)

4

Who commonly presents with Systemic Lupus Erythematous (SLE)?

1. Female (9:1)
2. Young (20% before 16, 65% between 16-55)
3. Afro-Caribbean > Asian > Caucasian

5

What are the Classification Criteria for Systemic Lupus Erythematous (SLE)?

Any 4 of:
1. Malar Rash (Butterfly Rash)
2. Discoid Rash (Raised, Scarring, Permanent, Alopecia)
3. Photosensitivity
4. Oral Ulcers
5. Arthritis (2 Joints at least)
6. Serositis (Pleurisy or Pericarditis)
7. Renal (Significant proteinuria / cellular cast in urine)
8. Neurological (unexplained seizures / psychosis)
9. Haematological (Low WCC, Platelets, Lymphocytes, Haemolytic Anaemia)
10. Immunological (Lupus anticoagulant, Low complement)
11. Anti-Nuclear Antibodies (ANA)

6

Who commonly presents with a Scleroderma Disorder?

1. Female (3:1)
2. Middle Ages (30 - 50 years old)

7

What are the Scleroderma Disorders?
How do they present?

A Heterogenous Group of Conditions linked by the presence of Thickened, Sclerotic Skin Lesion
Note - Other manifestations of these conditions are quite diverse

8

How do Scleroderma Disorders present?

The Presence of Thickened, Sclerotic Skin Lesion
Note - Other manifestations of these conditions are quite diverse

9

What are the 3 types of Scleroderma Disorders?

1. Morphea
2. Limited
3. Diffuse

10

What are some complications of Limited Scleroderma Disorders?

Pulmonary Hypertension

11

What are some complications of Diffuse Scleroderma Disorders?

1. Pulmonary Fibrosis
2. Renal Crisis
3. Small Bowel Bacterial Overgrowth

12

Who presents with Sjogren's Syndrome?

1. Female (9:1)
2. Middle Aged (40 - 50 years old)

13

What is the common presentation of Sjogren's Syndrome?

1. Dry eyes and Mouth
2. Parotid Gland Enlargement
3. (1/3 have) Systemic Upset:
3. a) Fatigue
3. b) Fever
3. c) Myalgia (Muscle Pain)
3. d) Arthalgia (Joint Pain)

14

What are some other presentations of Sjogren's Syndrome?

1. G.I.: Dysphagia / Abnormal Oesophageal Motility
2. CNS: Fits / Hemiplegia / Ataxia / Cranial Nerve Lesions
3. Dermatology: Raynaud's Syndrome
4. Joints: Arthalgia

15

What are complications of Sjogren's Syndrome?

1. Lymphoma
2. Neuropathy
3. Purpura
4. Interstitial Lung Disease
5. Renal Tubular Acidosis

16

How does Auto-Immune Myositis present?

Systemic, Diffuse, Proximal Muscle Weakness:
1. Polymyositis
2. Dermatomyositis:
2. a) Gottron's Papules (80%)
2. b) Heliotrope Rash (30-60%)
Note - The muscle weakness causes difficulty of dialy activities

17

What are the complications of Auto-Immune Myositis?

1. Cancer
2. Interstitial Lung Disease

18

What are some presentations of Mixed Connective Tissue Diseases?

1. Soft Tissue Swelling
2. Raynaud's Disease
3. Myositis
4. Arthalgia

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