Flashcards in 84. Sulfasalazine Deck (10):
Sulfasalazine - Mechanism
A combination of sulfapyridine (antibacterial) and 5-aminosalicylic acid (anti-inflammatory).
Activated by colonic bacteria.
Sulfasalazine - Clinical use
Ulcerative colitis, Crohn disease (colitis component).
Sulfasalazine - Adverse effects
Malaise, nausea, sulfonamide toxicity, reversible oligospermia.
• For a 24-year-old man with ulcerative colitis, you prescribe a medication that is a combination of two drugs. What are these?
Sulfapyridine and 5-aminosalicylic acid (the medicine is sulfasalazine)
• What is the function of sulfapyridine?
It is an antibiotic
• What activates sulfasalazine in the gut? Be specific.
Colonic bacteria activate sulfasalazine
• A patient is on sulfasalazine. What two diseases is the drug typically used to treat?
Crohn disease (for the colitis component) and ulcerative colitis
• A 30-year-old man starts on a drug composed of sulfapyridine and 5-aminosalicylic acid for Crohn disease. Side effects to be monitored for?
Reversible oligospermia, malaise, nausea, sulfonamide toxicity (this is sulfasalazine)
• A patient is found to have Crohn ileitis and asks if he can be started on sulfasalazine. What is the appropriate response?
Sulfasalazine would be ineffective, because it is activated by colonic bacteria and thus has no effect proximal to the colon