85. Ondansetron Flashcards Preview

Gastrointestinal > 85. Ondansetron > Flashcards

Flashcards in 85. Ondansetron Deck (8)
1

Ondansetron - MECHANISM

5-HT3 antagonist; Decreased vagal stimulation. Powerful
central-acting antiemetic.

2

Ondansetron - CLINICAL USE

Control vomiting postoperatively and in patients
undergoing cancer chemotherapy

3

Ondansetron - ADVERSE EFFECTS

Headache, constipation, QT interval
prolongation.

4

• Ondansetron is an antagonist of what receptor type?

5-hydroxytryptamine3

5

• Ondansetron is used to control vomiting primarily in which two settings?

After surgery and in conjunction with cancer chemotherapy (if you are feeling queasy at a party, keep on dancing with ondansetron)

6

• You give a 47-year-old woman a 5-HT3 antagonist for her nausea while she gets chemotherapy. What two main toxicities should you look for?

Headache and constipation (this is ondansetron)

7

• What is the mechanism of action for ondansetron?

It binds 5-HT3 receptors and antagonizes them, decreasing vagal stimulation

8

• In the ED, you see a patient receiving a 5-HT3 antagonist for nausea, and are told to recheck her ECG. Why?

The patient is receiving ondansetron, which decreases vagal stimulation and may cause QT prolongation

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