Flashcards in 85. Ondansetron Deck (8)
Ondansetron - MECHANISM
5-HT3 antagonist; Decreased vagal stimulation. Powerful
Ondansetron - CLINICAL USE
Control vomiting postoperatively and in patients
undergoing cancer chemotherapy
Ondansetron - ADVERSE EFFECTS
Headache, constipation, QT interval
• Ondansetron is an antagonist of what receptor type?
• Ondansetron is used to control vomiting primarily in which two settings?
After surgery and in conjunction with cancer chemotherapy (if you are feeling queasy at a party, keep on dancing with ondansetron)
• You give a 47-year-old woman a 5-HT3 antagonist for her nausea while she gets chemotherapy. What two main toxicities should you look for?
Headache and constipation (this is ondansetron)
• What is the mechanism of action for ondansetron?
It binds 5-HT3 receptors and antagonizes them, decreasing vagal stimulation