Flashcards in 8.6 Deck (14):
What is the clinical use of Mupirocin?
• Eradication of nasal colonization with MRSA in
adult patients and healthcare workers
• Treatment of impetigo or secondary infected traumatic skin lesions due to S.aureus or
What is the MOA of Mupirocin?
• Binds to bacterial isoleucyl transfer-RNA synthetase
resulting in the inhibition of protein synthesis
Which drugs affect Nucleic Acid Synthesis? (3)
What is the MOA of fluoroquinolones?
• Enter bacterium via porins
• Inhibit bacterial DNA replication via interference with
topoisomerase II (DNA gyrase) & IV
What is Levofloxacin ideal for?
Excellent activity against
Fluoroquinolones have their absorption affected by what?
What are the adverse effects of Fluoroquinolones?
• GI distress
• CNS, rash, photosensitivity
• Connective tissue problems (avoid in pregnancy, nursing mother, under 18’s) – Black Box Warning! (Esp in ankle - can be irreversible)
• QT prolongation (moxifloxacin, gemifloxacin,
• High risk of causing superinfections (C.difficile, C
What are the Sulfonamides?
What organisms are sulfonamides used for?
Bacteriostatic against gram + and gram -organisms?
Sulfonamides compete with what in it's MOA?
(inhibits Folic Acid synthesis)
What are the clinical applications of Sulfonamides?
Infrequently used as single agents (resistance)
• Topical agents (ocular,
• Oral agents (simple UTI’s)
• Sulfasalazine (oral) = ulcerative colitis, enteritis, IBD
What are the adverse effects of Sulfanomides?
• GI distress, fever, rashes, photosensitivity are common
• Crystalluria nephrotoxicity)
• Hypersensitivity reactions
• Hematopoietic disturbances (esp. patients with G6PD
• Kernicterus (in newborns and infants <2 months)
What are some drug reactions with Sulfonamides?
•Warfarin, phenytoin and methotrexate can lead to
increased plasma levels