9.29 Immunity 4 Flashcards Preview

8501 Clin Med > 9.29 Immunity 4 > Flashcards

Flashcards in 9.29 Immunity 4 Deck (46):
1

Humoral immunity is mediate by:

antibodies in
- saliva
- blood
- vaginal secretions
- other bodily fluids (macromolecules)

2

B cells are coated in __ and have specific receptor sites for ____

- immunoglobulin
- antigen

3

Once an antigen is identified, B cells are converted into these

plasma, or memory B cells

4

What happens once B cells are converted to plasma or memory B cells?

they circulate and look for a specific antigen to attack

5

antibody produced for the PRIMARY IMMUNE RESPONSE

IgM

6

IgM is located here

in the vasculature

7

antibody produced for ANTIBACTERIAL AND ANTIVIRAL function

IgG

8

IgG is located here

- found in blood
- ONLY antibody to cross the placenta!

9

antibody produced to protect the body's surfaces

IgA

10

IgA is found here

- mucus membranes
- body secretions

11

antibody produced to control activation or suppression

IgD

12

antibody produced for parasitic and ALLERGIC REACTIONS

IgE

13

How does IgE affect allergic reactions?

activates mast cells and histamine

14

What happens to IgG with a hemolytic disease?

the fetus can treat IgG as non-self invaders and break down the RBCs

15

t-cell immunity (cell mediated) protects against

protects host agains infection by intracellular pathogens

- viruses
- some bacteria

16

In addition to intracellular pathogens, cell mediated immunity is also responsible for

- transplant rejection
- contact dermatitis
- some autoimmune diseases

17

T-cells interact with

a specific antigen

18

T-cells produce

sensitized t-cells

19

What are the sensitized T cells called?

helper T-cells

20

What do helper T cells do?

- activate macrophages and NK cells from innate immunity
- help cytotoxic T-cells destroy viruses

21

What are regulatory/suppressor T-cells?

help prevent autoimmune disease by SUPPRESSING activation of an immune response

22

What happens when a host is re-exposed?

secondary immune response is generated

- memory T cells rapidly differentiate into effectors for a quicker response
- called IMMUNOLOGIC memory

23

Immunologic memory is the basis for

vaccination

24

Where are Peyer's patches located?

small intestine

25

What are Peyer's patches?

- lymphatic tissue in the ileum that monitors intestinal bacteria
- helps prevent growth of pathogens

26

Where in the body does the immune response occur?

- lymph nodes
- spleen
- mucosa tissue (tonsils, adenoids, Peyer's patches)

27

Spleen has a major role with

filtration of blood

28

problem with ruptured spleen

liver has to take over the role of blood filtration

29

Overview of immune response

- pathogen enters
- innate immunity (complement system recognizes and destroys)
- if no innate immunity available, acquired immunity must step in

30

factors affecting immunity (lots)

- aging
- nutrition
- environmental pollution
- trauma or illness
- meds
- spleen fx
- stress
- psychosocial
- burns
- surgery
- socioeconomic status
- exercise

31

effect of exercise on immunity

can enhance or suppress depending on the intensity

32

With this type of exercise, immunity is enhanced

moderate exercise

33

How is immunity enhanced by moderate exercise?

- can prevent effects of stress
- increases phagocytic activity of neutrophils and macrophages
- NK enhancement

34

What happens to immunity after intense/long duration exercise?

immunity is impaired immediately following

35

How is immunity impaired following intense/long duration exercise?

NK cells and cytolytic activity declines but only briefly

36

Brisk exercise increases WBC in proportion to ______, then does this

- effort
- decreases below normal for several hours after intense exercise

37

Strenuous exercise (minimum 80% VO2max) can evoke

acute phase response (innate immunity)

38

Regular exercise/acute bout of exercise MAY give some protection against

chronic systemic low-grade inflammation

39

intense exercise and older people

- may be detrimental
- BUT a lifetime of MODERATE exercise and activity are positive

40

How long do aged adults need to recover from acute effects of severe exercise?

6-24 hours

41

"severe" exercise

perceived intensity is critical and differs with each individual

42

Exercise can delay

apoptosis

43

Accelerated apoptosis is seen with this disease

Alzheimer's

44

When should strenuous exercise be avoided?

during an infectious episode

45

What is different about post workout with older adults and younger people?

older adults: immune system isn't being suppressed right after a moderate workout like their younger counterparts

46

What is the neck check?

if you have symptoms above the neck, stop and consider whether you should exercise

At half the intensity after 10 mins:

- if symptoms are better, can ramp up to full intensity and feel fine
- If symptoms are the same or worse, you may want to completely stop exercise

Decks in 8501 Clin Med Class (102):