Flashcards in 9.29 Immunity 4 Deck (46):
Humoral immunity is mediate by:
- vaginal secretions
- other bodily fluids (macromolecules)
B cells are coated in __ and have specific receptor sites for ____
Once an antigen is identified, B cells are converted into these
plasma, or memory B cells
What happens once B cells are converted to plasma or memory B cells?
they circulate and look for a specific antigen to attack
antibody produced for the PRIMARY IMMUNE RESPONSE
IgM is located here
in the vasculature
antibody produced for ANTIBACTERIAL AND ANTIVIRAL function
IgG is located here
- found in blood
- ONLY antibody to cross the placenta!
antibody produced to protect the body's surfaces
IgA is found here
- mucus membranes
- body secretions
antibody produced to control activation or suppression
antibody produced for parasitic and ALLERGIC REACTIONS
How does IgE affect allergic reactions?
activates mast cells and histamine
What happens to IgG with a hemolytic disease?
the fetus can treat IgG as non-self invaders and break down the RBCs
t-cell immunity (cell mediated) protects against
protects host agains infection by intracellular pathogens
- some bacteria
In addition to intracellular pathogens, cell mediated immunity is also responsible for
- transplant rejection
- contact dermatitis
- some autoimmune diseases
T-cells interact with
a specific antigen
What are the sensitized T cells called?
What do helper T cells do?
- activate macrophages and NK cells from innate immunity
- help cytotoxic T-cells destroy viruses
What are regulatory/suppressor T-cells?
help prevent autoimmune disease by SUPPRESSING activation of an immune response
What happens when a host is re-exposed?
secondary immune response is generated
- memory T cells rapidly differentiate into effectors for a quicker response
- called IMMUNOLOGIC memory
Immunologic memory is the basis for
Where are Peyer's patches located?
What are Peyer's patches?
- lymphatic tissue in the ileum that monitors intestinal bacteria
- helps prevent growth of pathogens
Where in the body does the immune response occur?
- lymph nodes
- mucosa tissue (tonsils, adenoids, Peyer's patches)
Spleen has a major role with
filtration of blood
problem with ruptured spleen
liver has to take over the role of blood filtration
Overview of immune response
- pathogen enters
- innate immunity (complement system recognizes and destroys)
- if no innate immunity available, acquired immunity must step in
factors affecting immunity (lots)
- environmental pollution
- trauma or illness
- spleen fx
- socioeconomic status
effect of exercise on immunity
can enhance or suppress depending on the intensity
With this type of exercise, immunity is enhanced
How is immunity enhanced by moderate exercise?
- can prevent effects of stress
- increases phagocytic activity of neutrophils and macrophages
- NK enhancement
What happens to immunity after intense/long duration exercise?
immunity is impaired immediately following
How is immunity impaired following intense/long duration exercise?
NK cells and cytolytic activity declines but only briefly
Brisk exercise increases WBC in proportion to ______, then does this
- decreases below normal for several hours after intense exercise
Strenuous exercise (minimum 80% VO2max) can evoke
acute phase response (innate immunity)
Regular exercise/acute bout of exercise MAY give some protection against
chronic systemic low-grade inflammation
intense exercise and older people
- may be detrimental
- BUT a lifetime of MODERATE exercise and activity are positive
How long do aged adults need to recover from acute effects of severe exercise?
perceived intensity is critical and differs with each individual
Exercise can delay
Accelerated apoptosis is seen with this disease
When should strenuous exercise be avoided?
during an infectious episode
What is different about post workout with older adults and younger people?
older adults: immune system isn't being suppressed right after a moderate workout like their younger counterparts