9.29 Immunity 4 Flashcards Preview

8501 Clin Med > 9.29 Immunity 4 > Flashcards

Flashcards in 9.29 Immunity 4 Deck (46)
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1

Humoral immunity is mediate by:

antibodies in
- saliva
- blood
- vaginal secretions
- other bodily fluids (macromolecules)

2

B cells are coated in __ and have specific receptor sites for ____

- immunoglobulin
- antigen

3

Once an antigen is identified, B cells are converted into these

plasma, or memory B cells

4

What happens once B cells are converted to plasma or memory B cells?

they circulate and look for a specific antigen to attack

5

antibody produced for the PRIMARY IMMUNE RESPONSE

IgM

6

IgM is located here

in the vasculature

7

antibody produced for ANTIBACTERIAL AND ANTIVIRAL function

IgG

8

IgG is located here

- found in blood
- ONLY antibody to cross the placenta!

9

antibody produced to protect the body's surfaces

IgA

10

IgA is found here

- mucus membranes
- body secretions

11

antibody produced to control activation or suppression

IgD

12

antibody produced for parasitic and ALLERGIC REACTIONS

IgE

13

How does IgE affect allergic reactions?

activates mast cells and histamine

14

What happens to IgG with a hemolytic disease?

the fetus can treat IgG as non-self invaders and break down the RBCs

15

t-cell immunity (cell mediated) protects against

protects host agains infection by intracellular pathogens

- viruses
- some bacteria

16

In addition to intracellular pathogens, cell mediated immunity is also responsible for

- transplant rejection
- contact dermatitis
- some autoimmune diseases

17

T-cells interact with

a specific antigen

18

T-cells produce

sensitized t-cells

19

What are the sensitized T cells called?

helper T-cells

20

What do helper T cells do?

- activate macrophages and NK cells from innate immunity
- help cytotoxic T-cells destroy viruses

21

What are regulatory/suppressor T-cells?

help prevent autoimmune disease by SUPPRESSING activation of an immune response

22

What happens when a host is re-exposed?

secondary immune response is generated

- memory T cells rapidly differentiate into effectors for a quicker response
- called IMMUNOLOGIC memory

23

Immunologic memory is the basis for

vaccination

24

Where are Peyer's patches located?

small intestine

25

What are Peyer's patches?

- lymphatic tissue in the ileum that monitors intestinal bacteria
- helps prevent growth of pathogens

26

Where in the body does the immune response occur?

- lymph nodes
- spleen
- mucosa tissue (tonsils, adenoids, Peyer's patches)

27

Spleen has a major role with

filtration of blood

28

problem with ruptured spleen

liver has to take over the role of blood filtration

29

Overview of immune response

- pathogen enters
- innate immunity (complement system recognizes and destroys)
- if no innate immunity available, acquired immunity must step in

30

factors affecting immunity (lots)

- aging
- nutrition
- environmental pollution
- trauma or illness
- meds
- spleen fx
- stress
- psychosocial
- burns
- surgery
- socioeconomic status
- exercise

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