A &A (BBCH24 and A&ABB) Flashcards Preview

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Flashcards in A &A (BBCH24 and A&ABB) Deck (122)
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1

what is the recommended acclimation period for rodents?

24-72hrs

2

what class of anesthetic are ketamine and tiletamine in?

dissociative

3

effects produced by ketamine

a degree of analgesia and immobility without muscle relaxation, adequate for restraint but not for anesthesia

4

what class of anesthetic are barbituates (sodium pentobarbital) in?

sedative hypnotics

5

effects produced by barbiturates?

minimal analgesic effect, affect consciousness, dose related respiratory and cardiovascular depression, decreased cerebral blood flow and intracranial pressure

6

mechanism and classification of Inactin

barbituate, sedative hypnotic

7

uses of Inactin

long duration of anesthesia, 3hrs or more in the rat

8

considerations for Propofol

1) alkylphenol derivative 2) respiratory and cardiovascular depression 3) resembles thiopental 4) rapid recovery

9

another name for Avertin

Tribromoethanol

10

considerations for the use of Avertin

short surgical procedures give IP but degradation products are irritants and toxic so may be recommended for terminal procedures only but has been used in transgenic mouse production narrow safety margin- respiratory and circulatory depression, generally unpredictable

11

describe neuroleptics

combination of potent opioids and butyrophenone tranquilizers

12

effects of alpha-chloralose

minimal analgesia, not recommended for painful manipulations, used in studies of long duration while preserving autonomic reflexes, not suitable for survival procedures due to rough induction, prolonged recovery and seizures

13

uses for chloral hydrate

sedative hypnotic, medium duration light anesthesia with minimal effects on cardiovascular function or reflexes, associated with peritonitis and adynamic ileus, carcinogenic

14

properties of urethane

(aka ethyl carbamate) greater analgesia, prolonged stable anesthesia in rats, liver and pulmonary damage and carcinogenic, not suitable for recovery anesthesia

15

effects of metomidate and etomidate

rapid loss of consciousness, minimal analgesia, good cardiovascular stability, bad in that it suppresses the adrenocortical function of some species

16

sevoflurane+rats+soda lime= ?

compound A- nephrotoxic

17

receptor for Buprenorphine?

partial mu agonist

18

example of alpha2 agonists

xylazine, dexmedetomidine

19

side effects of alpha2 agonists

hyperglycemia, bradycardia, vasoconstriction, hypothermia

20

side effects of additional dosing of alpha2 agonists

bradycardia and cardiac arrest

21

reversal for alpha2 agonists

atipamezole

22

examples of benzodiazepines

diazepam and midazolam

23

effects of benzodiazepines

anxiolysis, sedation, and muscle relaxation, not analgesic

24

reversal of benzodiazepines

flumazenil

25

what form of post op care has been shown to significantly increase rates of pregnancy and fetal implantation?

supplemental heat overnight

26

what are the considerations of anesthetics for mouse fetal surgery and why?

isoflurane causes uterine relaxation alpha2 agonists reduce uterine blood flow and increase uterine contractility

27

effects of isoflurane anesthesia

1) cardio and neuro protective 2) little to no GI and liver 3) mixed on the lungs (can cause cilliary disfunction) 4) leukopenia, neutropenia, thrombocytopenia in C3H/HeN mice 5) hypogylcemia and metabolic acidosis in neonatal mice

28

effects of halothane anesthesia

1) most extensive effects on cardiopulmonary system 2) potent bronchodilator 3) neuroprotective 4) sustained elevation in cortisterone for up to 24 hours

29

effects of sevoflurane anesthesia

1) cardioprotective and neuroprotective (brain not spinal cord) 2) does not affect tracheal epilethial cell cilliary function 3) nephrotoxic for rats (compound A)

30

effects of desflurane anesthesia

1) quick recovery 2) neuroprotective 3) cardioprotective (even during and after infarct, potential treatment)