ABX Review Flashcards by Cat Johnson

Pseudomonas Drugs

Pseudo Penis Forgets a Mother-pecking Condom(2)
Piptazo
FQ
Aminogycosides
Monobactam
Polymyxin
Cefepime, Carbapenem

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Kill MRSA with

“Long Late Cram Sesh, Very Tired”
L-Lincosamide
L-Linezolid
C- Clindamycin
S-Sulfonamide
V-Vanco (IV)
T-TCN

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What Drugs mentioned are very Nephrotoxic?

“A Very Angry “C”idney”
A-Amphotericin B
Vanco
Aminoglycosides- ATN
Carbapenems

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What ABX (and antifungals) are Hepatotoxic?

All The DCRIMES
All-Azoles
The-Terbinafine
D- Doxycycline
C- Clindamycin
R- Rifampin
I- Isoniazid
M- Metronidazole
E- Erythro-like (not Azithro)
S- Sulfa

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What Drugs inhibit CYP?

“Clarice is back at war, inhibit her”
Clarithromycin
Bactrim
Azoles
Wafarin -Check INR (may be high)
Inhibit CYP

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What drugs induce CYP?

Ripe cervix= induce labor
Rifampin

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What drugs cover Lyme Dz?

Lyme Dz “LATA”
Lyme
Augmented PCNS
TCN
Amoxicillin/Ampicillin

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Anaerobe coverage above the diaphragm

“clear lungs”
Clindamycin-Lincosamide

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Anaerobe coverage below the diaphragm

“My Tummy”
Metronidazole Tinidazole”

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H.flu coverage

“BUM CAT”
B-Bactrim
U-Unasyn
M-Macrolides
C-Cefurixime
A-Augmentin
T-TCN

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Bacteriostatic Drugs

“Static Like SMs Texts”
Like-Lincosamide
S-Sulfa
M-Macrolides
s
Texts- TCN

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When would you use IV vs oral?

*Pt condition
*MRSA risk
*Don’t tolerate/absorb oral Rx
ie Crohns & gastric Bypass
*Outpt IV rx:
Dalbavancin & Aritavancin
both 1 IV infusion x2wks.
- These are NOT for IVDU

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What abx inhibits 50s ribosome synthesis

Macrolides
Clindamycin

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What abx inhibits 30S ribosome synthesis

Aminoglycosides
TCNs

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What Abx inhibits 30S & 50S ribosome synthesis

Linezolid

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What abx inhibits folic acid producion

Sulfonamides

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What abx inhibit cell wall synthesis

PCN
Cephs
Vanco

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What abx inhibits cell membrane synthesis

Polymyxin

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What abx inhibits DNA gyrase

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What abx inhibits RNA polymerase

Rifampin

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DO PCNs cover MRSA?

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Which 3 abx cause diarrhea?

Augmentin
Clindamycin
Erythromycin (pro motility agent)

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What abx is given before surgery

Ancef (cefazolin)

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what abx class for cellulitis,strep pharyngtits,syphillis?

Natural pcn

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what are the aminopcns? can they cover lyme dz <8yo?

ampicillin/amoxicillin yes

what abx are used for endocarditis prophylaxis?

ampicillin amoxicillin

you are bit by a dog: what is the bug? What is the DOC?

Pasteurella Augmentin (or unasyn)

you are bit by a dog: Can the DOC cover dental infections? Why?

yes covers anaerobes

you are bit by a dog: Can the DOC also cover your AECB? why? what other drug class is an alternative?

yes Hflu coverage 2nd gen ceph- Cefuroxime PO

you are bit by a dog: Can the DOC cover lyme dz? why? What other abx cover this bug?

yes covers borrelia burgdorfi Amino-pcns (amoxicillin/ampicillin) & TCNs

you are bit by a dog: also ate soft cheese. uh oh. which bug? is it covered by the abx for the dog bite? What other drug covers this bug?

yes Listeria aminoPCN's: Ampicillin/amoxicillin

Which PCN class covers staph and MSSA? Can they also cover Strep?

Anti-staph PCN Nafcillin Dicloxacillin yes

Do the natural PCN cover staph?

nope

what ceph gen covers uncomplicated cystitis?

1st gen

you are dx w/Ghonorrhea, whoops. What is the bug morphology

gram - diplococci

you are dx w/Ghonorrhea, What is DOC?

Ceftriaxone

you are dx w/Gonorrhea AND meningitis what DOC? why?

Ceftriaxone, crosses BBB

what s/e do we worry about w/ceftriaxone

biliary sluge pseudocholelithiasis

why do we not mix Tetracyclines with isotrentinoin (accutane)?

Pseudotumor cerebri (Idiopathic intracranial HTN) TCNs are used as skin care abx-good to know

You are hospitalized and have ESBL what is DOC?

Carbapenems

You are hospitalized and have ESBL AND have Pseudomonas DOC? Can this class cover ventilator pna?

Carbapenems (not erta) yes!

2 bad s/e of carbapenems?

Seizures Nephrotoxicity

2 Drug classes that cover walking pna (mycoplasma)

TCNs Macrolides

2 drug classes that cover atypical pna (legionella)

TCN Macrolides

3 tic borne illnesses that TCN's cover

Rickettsia, Ehrlichia, Borrelia

Can you give TCN to kids <8 with tic illnesses

yes

what 2 drug classes cause photosensitivity?

TCN FQ

what is the drug & dose for chlamydia?

Doxy 100mg BID x7d

What 3 drugs/classes cause QT prolongation?

"FQt-AzAz" Azithromycin FQ's Azoles

You hear a Whoop from your child bug? DOC?

Pertussis Macolides

Now you have the whoop cough AND Chlamydia DOC? will this drug cover staph?

Macrolides no

You have urethritis and cervicitis DOC? Can you use this drug for CAP?

Macrolides Yes- but as Azithro + Doxy

You have an anerobic infect in lungs, DOC? Can this drug cover strep & Staph?

Clindamycin yes

What drug can you substitute for serious b lactam allergy in skin and soft tissue infections and strep pharyngitis AND dental infect

Clindamycin

What drug has high incidence of C-diff

Clindamycin

What 2 drugs lose absorption when taken with Ca2+

TCN FQ

Name 8 ADRs of FQ's

Arthropathy Tendinopathy CNS toxicity QT prolongation Photosensitivity contraindicated in pregnancy/<18yo Dysglycemia Neuropathy

What drug class causes dysglycemia

What drug class is used for pyelonephritis?

What drug class is used for prostatitis?

What drug class is used for travelers diarrhea?

What drug class is used for diverticulitis?

FQ + Metronidazole

What drug class covers PCP tx & prevention

Sulfonamides

What drug class covers Klebsiella & Proteus?

Sulfonamides

What drug class causes retentio of potassium?

BK-Big (Bactrim) K+ Sulfonamides

What drug class needs renal dosing

Sulfonamides

What drug class causes Type 1 & 4 Hypsersensitivity rxns? Name them

Sulfonamides Type 1- sulfa rash Type 4- SJS & TEN

What drug class causes myelosuppression?

Sulfonamides

What 2 drug classes cause Hemolytic anemia in G6PD?

Sulfonamides (Bactrim) Nitrofuratonin (Macrobid)

What 4 drug classes can cover Uncomplicated cystitis (not pyelo)? What 3 classes cover Complicated UTI (pyelo)?

1st gen cephalosporins (Cefazolin, Cefalexin) Sulfonamides Nitrofuratonin (Macrobid) Fosfomycin 3rd gen cephs (Ceftriaxone) Carbapenems FQ

What drugs can cover: Fungal UTI? ESBL?

Fluconazole Carbapenems Nitrofuratonin (Macrobid) Fosfomycin (Monurol)

you are dx with protozoas: giardia & trich (oh dear) DOC? esp w/what other drug?

Metronidazole w/FQ

You are dx with BV (yikes) DOC?

Nitroimidazoles (Metronidazole & tinidazole)

What drug causes a disulfram rx w/ETOH? what is a disulfram rxn?

Metronidazole & Tinidazole facial flushing, tachy, N/V/D

What drug class causes fetotoxicity in 1st trimester

Metronidazole & tinidazole

What drug class do you need to measure peaks & troughs (narrow therapeutic window)? What other class same same but not for oral

Aminoglycosides Glycopeptides (Vanco IV)

What drug clas can cause ATN?

Aminoglycosides

What 2 abx classes (&1 spec abx) are linked to ototoxicity?

Aminoglycosides: Gentamycin Vancomycin

Ototoxicity & nephrotoxicity Which can be reversible? how?

Nephrotoxicity- stop the drug

What is Red Man syndrme?

A histamine response to fast push IV Vanco

Do nitrofuratonin and monurol (fosfomycin) have systemic absorption?

no only works in the bladder

Which TB drugs ↑ liver enzymes (esp w/etoh)

Rifampin & Isoniazid

What can you take with isoniazid to decrease the periph neuropathy?

B6- Pyridoxime

Which cephalosporin gen has BROAD COVERAGE and MRSA?

Next gen (5th) Ceftaroline (Teflaro)

Which drug class covers Mycoplasma (atypical pna), H.pylori, Chlamydia, and Pertussis

Macrolides

What drugs cause metallic taste?

Clarithroycin Nitroimidazole (Metronidazole & Tinidazole)

What is red lobster syndrome?

A general redness caused by riampin (with orange urine)

What drug causes color blindness?

Ethambutol

What drug causes polyarthralgia? What can you do to treat it?

Pyrazidimine NSAIDS

Cat C Drugs

"F**k Bad Children" FQ Bactrim Clarithromycin

Cat D Drugs

"CATs are Destructive" C- Cat D Aminoglycosides TCNs

FAST AbX

FQ- Arthtropathy Aminoglycosides- Ototoxicity S-Sulfonamides- infantile kernicterus T-TCN- Bone & teeth probs

Type 1 Rxn & 2 examples

IgE anaphylaxi, urticaria

Type II & 2 examples

"B and the number 2 are complements" IgG and complement Bone marrow suppression & blood transfusion rxn

Type III rxn & 4 examples

Ab-Ag complexes PSGN Serum Sickness SLE nephritis RA

Type IV rxn & 4 examples

T-cell (delayed) SJS TEN Organ txfr Poison ivy (contact dermatitis)

Are we gonna crush this test?

HELL YEAH