ACE-1, Antihypertensive Flashcards
(39 cards)
Benazepril —– Brand name, class and dosage forms?
Brand name: Lotensin
Class: ACE-I, Antihypertensive
Dosage forms: oral tablet (5, 10, 20, 40mg)
Benazepril —– Indication?
Hypertension
Benazepril —– MOA?
Competitive ACE-I; It also reduces serum aldosterone, leading to decreased sodium retention, potentiates the vasodilator kallikrein–kinin system, and can alter prostanoid metabolism, inhibit the sympathetic nervous system, and inhibit the tissue renin-angiotensin system.
Benazepril—– contraindication?
hypersensitivity, history of angioedema, anuria, concomitant use with aliskiren in pt with DM, concurrent sacubitrul
Benazepril—–efficacy monitoring parameters?
Decreased BP
Benazepril—- key patient counseling points?
Avoid in pregnancy
Seek immediate medically attention if you experience an facial swelling
most common adverse effect is a dry cough
use potassium supplements or salt substitutes under under medical supervision
may cause dizziness (worsens with dehydration)
take at the same time everyday
Benazepril—– ADR?
Common: none
Less common: Diarrhea, orthostatic dizziness, dry cough, fatigue, headache, hyperkalemia, nausea, nephrotoxicity, rash, tachycardia, vomiting
serious: angioedema (facial swelling), birth defects, liver failure, stevens-Johnson syndrome
Enalapril —– Brand name, class, and dosage forms?
Brand name: Vasotec
Class: ACEI, antihypertensive
Dosage form: oral tablet and oral solution
Enalapril —– indications?
Heart failure
HTN
Kidney disease (non-DM)
Enalapril—- MOA?
prodrug that is rapidly converted to its active metabolite, enalaprilat, a competitive ACEI. It reduces serum aldosterone, leading to decreased sodium retention, potentiates the vasodilator kallikrein–kinin system, and inhibits the sympathetic nervous system and tissue renin-angiotensin system. The net effect is reduction in total peripheral resistance and BP in hypertensive patients and reduction in elevated afterload in patients with heart failure.
Enalapril —– Contraindications?
hypersensitivity to enalapril, history of angioedema, pregnancy, concurrent sacubitril
Enalapril —–ADR?
common: increased SCr
Less common: diarrhea, dizziness, dry cough, fatigue, headache, hypotension, hyperkalemia, nausea, nephrotoxicity, rash, tachycardia
serious: angioedmea, birth defects and liver failure
Enalapril —–efficacy monitoring parameters?
decreased BP, signs of heart failure
enalapril —- toxicity monitoring parameters
signs of angioedema, severe persistent cough, hypotension, monitor baseline and periodic electrolytes, SCr, BUN, and urine protein
enalapril—– key patient counseling points?
Use potassium supplements or salt substitutes only under medical supervision. Report signs/symptoms of angioedema. May cause dizziness that may worsen if dehydrated. Use caution rising from sitting or lying position, especially when initiating treatment.
Lisinopril—– brand name, dosage form, and class
brand name: Prinivil and Zestril
class: ACEI, antihypertensive
dosage form: oral tablet (2.5, 5, 10,20, 30, 40) and oral solution
lisinopril—–indications?
ST-segment elevation MI
Heart failure with reduced ejection fraction
HTN
Lisinopril ——- MOA?
Lisinopril is a competitive ACEI. It also reduces serum aldosterone, leading to decreased sodium retention, potentiates the vasodilator kallikrein–kinin system, and can alter prostanoid metabolism, inhibit the sympathetic nervous system, and inhibit the tissue renin-angiotensin system.
lisinopril —– contraindications?
Hypersensitivity to lisinopril or other ACEIs, history of ACEI-induced angioedema, and hereditary or idiopathic angioedema, concurrent use with aliskiren in diabetic patients, concurrent use with sacubitril
lisinopril —– ADR?
common: none known
less common: Diarrhea, dizziness, dry cough, headache, hypotension, hyperkalemia, nausea, nephrotoxicity, rash, tachycardia, vomiting
serious: angioedmea, birth defects, liver failure
Lisinopril—— monitoring?
efficacy- decreased BP
toxicity- Signs/symptoms of angioedema (swelling of the face, eyes, lips, tongue, or throat), severe persistent cough, hypotension; monitor baseline and periodic electrolytes, SCr, BUN, and urine protein.
Lisinopril ——key counseling points?
Avoid pregnancy. Use potassium supplements or salt substitutes only under medical supervision. May cause dizziness that may worsen if dehydrated.
**can be considered first line agent for HTN management in pt with PMH of DM, or HF w/ reduced ejection fraction
Quinapril—— brand name, class, and dosage form?
Brand name: Accupril
class: ACEI, antirhypertensive
dosage form: oral tablet
Quinapril—-Indications?
heart failure and HTN
